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<article article-type="review-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">akusherstvo</journal-id><journal-title-group><journal-title xml:lang="en">Obstetrics, Gynecology and Reproduction</journal-title><trans-title-group xml:lang="ru"><trans-title>Акушерство, Гинекология и Репродукция</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2313-7347</issn><issn pub-type="epub">2500-3194</issn><publisher><publisher-name>IRBIS LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17749/2313-7347/ob.gyn.rep.2024.456</article-id><article-id custom-type="elpub" pub-id-type="custom">akusherstvo-2054</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW ARTICLES</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НАУЧНЫЕ ОБЗОРЫ</subject></subj-group></article-categories><title-group><article-title>The mechanism of twins formation</article-title><trans-title-group xml:lang="ru"><trans-title>Механизм формирования двоен</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2492-3910</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кузнецов</surname><given-names>П. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kuznetsov</surname><given-names>P. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Павел Андреевич Кузнецов, к. м. н., доцент</p><p>лечебный факультет; кафедра акушерства и гинекологии</p><p>117997; ул. Островитянова, д. 1; Москва</p></bio><bio xml:lang="en"><p>Pavel A. Kuznetsov, MD, PhD, Associate Professor</p><p>Faculty of Medicine; Department of Obstetrics and Gynecology</p><p>117997; 1 Ostrovityanova Str.; Moscow</p></bio><email xlink:type="simple">poohsmith@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-3128-0967</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Плохих</surname><given-names>Е. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Plokhikh</surname><given-names>E. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Евгения Сергеевна Плохих, студент</p><p>117997; ул. Островитянова, д. 1; Москва</p></bio><bio xml:lang="en"><p>Evgeniya S. Plokhikh, Student</p><p>117997; 1 Ostrovityanova Str.; Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov Russian National Research Medical University, Health Ministry of Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>19</day><month>05</month><year>2024</year></pub-date><volume>18</volume><issue>2</issue><fpage>268</fpage><lpage>273</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Kuznetsov P.A., Plokhikh E.S., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Кузнецов П.А., Плохих Е.С.</copyright-holder><copyright-holder xml:lang="en">Kuznetsov P.A., Plokhikh E.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.gynecology.su/jour/article/view/2054">https://www.gynecology.su/jour/article/view/2054</self-uri><abstract><p>   What events in pregnant woman underlie twins formation? What do zygosity, chorionicity and amnionicity depend on? It seems that the answer is very clear. As early as in 1955, the works by G.W. Corner were published, which served as the basis for proposing the traditional model of twins formation, still remains widely acknowledged. But whether is everything so obvious? In order to answer this question, it is necessary to go back to the roots and understand of how the overall idea about fertilization and formation of multiple pregnancies has evolved since the XVII century till the present time.</p></abstract><trans-abstract xml:lang="ru"><p>   В результате каких процессов в организме беременной женщины происходит образование двоен? От чего зависит зиготность, хориальность и амниальность? Кажется, что ответ предельно ясен. Еще в 1955 г. были опубликованы работы американского эмбриолога Дж. В. Корнера, на основе которых была сформирована традиционная модель формирования двоен, которая по сей день пользуется популярностью. Но так ли всё очевидно? Для того чтобы ответить на этот вопрос,необходимо обратиться к истокам и понять, как же эволюционировало представление об оплодотворении в целом и об образовании многоплодной беременности, начиная с XVII века до настоящего времени.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>двойни</kwd><kwd>беременность</kwd><kwd>вспомогательные репродуктивные технологии</kwd></kwd-group><kwd-group xml:lang="en"><kwd>twins</kwd><kwd>pregnancy</kwd><kwd>assisted reproductive technologies</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Авторы заявляют об отсутствии финансовой поддержки</funding-statement><funding-statement xml:lang="en">The authors declare no funding</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Канаев И.И. Близнецы. Очерки по вопросам многоплодия. Институт физиологии имени И.П. Павлова. 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