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<article article-type="review-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">akusherstvo</journal-id><journal-title-group><journal-title xml:lang="en">Obstetrics, Gynecology and Reproduction</journal-title><trans-title-group xml:lang="ru"><trans-title>Акушерство, Гинекология и Репродукция</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2313-7347</issn><issn pub-type="epub">2500-3194</issn><publisher><publisher-name>IRBIS LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17749/2313-7347/ob.gyn.rep.2024.512</article-id><article-id custom-type="elpub" pub-id-type="custom">akusherstvo-2053</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW ARTICLES</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НАУЧНЫЕ ОБЗОРЫ</subject></subj-group></article-categories><title-group><article-title>Female magnesium deficiency and its management: review of current knowledge</article-title><trans-title-group xml:lang="ru"><trans-title>Дефицит магния у женщин и его контроль: обзор современных представлений</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7415-4633</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Макацария</surname><given-names>А. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Makatsariya</surname><given-names>A. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Александр Давидович Макацария, д. м. н., профессор, академик РАН, зав. кафедрой, вице-президент Российского общества акушеров-гинекологов (РОАГ), Заслуженный врач Российской Федерации, Почетный профессор Венского Университета</p><p>Клинический институт детского здоровья имени Н.Ф. Филатова; кафедра акушерства, гинекологии и перинатальной медицины</p><p>119991;  ул. Большая Пироговская, д. 2, стр. 4; Москва</p><p>Scopus Author ID: 57222220144; Researcher ID: M-5660-2016</p></bio><bio xml:lang="en"><p>Alexander D. Makatsariya, MD, Dr Sci Med, Academician of RAS, Professor, Head of the Department, Vice-President of the Russian Society of Obstetricians and Gynecologists (RSOG), Honorary Doctor of the Russian Federation, Emeritus Professor of the University of Vienna</p><p>Filatov Clinical Institute of Children’s Health; Department of Obstetrics, Gynecology and Perinatal Medicine</p><p>119991; 2 bldg. 4, Bolshaya Pirogovskaya Str.; Moscow</p><p>Scopus Author ID: 57222220144; Researcher ID: M-5660-2016</p></bio><email xlink:type="simple">gemostasis@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8404-1042</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бицадзе</surname><given-names>В. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Bitsadze</surname><given-names>V. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Виктория Омаровна Бицадзе, д. м. н., профессор РАН, профессор кафедры</p><p>Клинический институт детского здоровья имени Н.Ф. Филатова; кафедра акушерства, гинекологии и перинатальной медицины</p><p>119991;  ул. Большая Пироговская, д. 2, стр. 4; Москва</p><p>Scopus Author ID: 6506003478; Researcher ID: F-8409-2017</p></bio><bio xml:lang="en"><p>Viktoria O. Bitsadze, MD, Dr Sci Med, Professor of RAS, Professor</p><p>Filatov Clinical Institute of Children’s Health; Department of Obstetrics, Gynecology and Perinatal Medicine</p><p>119991; 2 bldg. 4, Bolshaya Pirogovskaya Str.; Moscow</p><p>Scopus Author ID: 6506003478; Researcher ID: F-8409-2017</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7456-2386</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Солопова</surname><given-names>А. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Solopova</surname><given-names>A. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Антонина Григорьевна Солопова, д. м. н., профессор</p><p>Клинический институт детского здоровья имени Н.Ф. Филатова; кафедра акушерства, гинекологии и перинатальной медицины</p><p>119991;  ул. Большая Пироговская, д. 2, стр. 4; Москва</p><p>Scopus Author ID: 6505479504; Researcher ID: Q-1385-2015</p></bio><bio xml:lang="en"><p>Antonina G. Solopova, MD, Dr Sci Med, Professor</p><p>Filatov Clinical Institute of Children’s Health; Department of Obstetrics, Gynecology and Perinatal Medicine</p><p>119991; 2 bldg. 4, Bolshaya Pirogovskaya Str.; Moscow</p><p>Scopus Author ID: 6505479504; Researcher ID: Q-1385-2015</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7663-710X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Громова</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Gromova</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ольга Алексеевна Громова, д. м. н., профессор, ведущий научный сотрудник</p><p>119333; ул. Вавилова, д. 44, корп. 2; Москва</p><p>Scopus ID: 7003589812; Author ID: 94901</p></bio><bio xml:lang="en"><p>Olga A. Gromova, MD, Dr Sci Med, Professor, Leading Researcher</p><p>119333; 44 bldg. 2, Vavilova Str.; Moscow</p><p>Scopus ID: 7003589812; Author ID: 94901</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0459-0488</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Корабельников</surname><given-names>Д. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Korabelnikov</surname><given-names>D. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Даниил Иванович Корабельников, к. м. н., профессор, ректор</p><p>кафедра внутренних болезней с курсами семейной медицины, функциональной диагностики, инфекционных болезней</p><p>123056; 2-я Брестская ул., д. 5, с. 1–1а;; Москва</p></bio><bio xml:lang="en"><p>Daniil I. Korabelnikov, MD, PhD, Professor, Rector</p><p>Department of Internal Medicine with Courses in Family Medicine, Functional Diagnostics, Infectious Diseases</p><p>123056; 5 bldg. 1–1a, 2-ya Brestskaya Str.; Moscow</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3367-9844</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Блинов</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Blinov</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дмитрий Владиславович Блинов, к. м. н., ассистент, доцент, руководитель по медицинским и научным вопросам</p><p>Институт клинической медицины имени Н.В. Склифосовского; кафедра спортивной медицины и медицинской реабилитации; кафедра спортивной, физической и реабилитационной медицины</p><p>119991;  ул. Большая Пироговская, д. 2, стр. 4; 123056; 2-я Брестская ул., д. 5, с. 1–1а; 127006; ул. Садовая-Триумфальная, д. 4–10; Москва</p><p>Scopus Author ID: 6701744871; Researcher ID: E-8906-2017; RSCI: 9779-8290</p></bio><bio xml:lang="en"><p>Dmitry V. Blinov, MD, PhD, MBA, Assistant, Head of Medical and Scientific Affairs, Associate Professor</p><p>Sklifosovsky Institute of Clinical Medicine; Department of Sports Medicine and Medical Rehabilitation; Department of Sports, Physical and Rehabilitation Medicine</p><p>119991; 2 bldg. 4, Bolshaya Pirogovskaya Str.; 123056; 5 bldg. 1–1a, 2-ya Brestskaya Str.; 127006; 4–10 Sadovaya-Triumfalnaya Str.; Moscow</p><p>Scopus Author ID: 6701744871; Researcher ID: E-8906-2017; RSCI: 9779-8290</p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0725-9686</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хизроева</surname><given-names>Д. Х.</given-names></name><name name-style="western" xml:lang="en"><surname>Khizroeva</surname><given-names>J. Kh.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Джамиля Хизриевна Хизроева, д. м. н., профессор</p><p>Клинический институт детского здоровья имени Н.Ф. Филатова; кафедра акушерства, гинекологии и перинатальной медицины</p><p>119991;  ул. Большая Пироговская, д. 2, стр. 4; Москва</p><p>Scopus Author ID: 57194547147; Researcher ID: F-8384-2017</p></bio><bio xml:lang="en"><p>Jamilya Kh. Khizroeva, MD, Dr Sci Med, Professor</p><p>Filatov Clinical Institute of Children’s Health; Department of Obstetrics, Gynecology and Perinatal Medicine</p><p>119991; 2 bldg. 4, Bolshaya Pirogovskaya Str.; Moscow</p><p>Scopus Author ID: 57194547147; Researcher ID: F-8384-2017</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2541-3843</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Макацария</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Makatsariya</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Наталия Александровна Макацария, к. м. н., доцент</p><p>Клинический институт детского здоровья имени Н.Ф. Филатова; кафедра акушерства, гинекологии и перинатальной медицины</p><p>119991;  ул. Большая Пироговская, д. 2, стр. 4; Москва</p><p>Researcher ID: F-8406-2017</p></bio><bio xml:lang="en"><p>Nataliya A. Makatsariya, MD, PhD, Associate Professor</p><p>Filatov Clinical Institute of Children’s Health; Department of Obstetrics, Gynecology and Perinatal Medicine</p><p>119991; 2 bldg. 4, Bolshaya Pirogovskaya Str.; Moscow</p><p>Researcher ID: F-8406-2017</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3628-0804</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Третьякова</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Tretyakova</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мария Владимировна Третьякова, к. м. н., врач акушер-гинеколог, ассистент</p><p>Клинический институт детского здоровья имени Н.Ф. Филатова; кафедра акушерства, гинекологии и перинатальной медицины</p><p>119991;  ул. Большая Пироговская, д. 2, стр. 4; Москва</p></bio><bio xml:lang="en"><p>Maria V. Tretyakova, MD, PhD, Obstetrician-Gynecologist, Assistant</p><p>Filatov Clinical Institute of Children’s Health; Department of Obstetrics, Gynecology and Perinatal Medicine</p><p>119991; 2 bldg. 4, Bolshaya Pirogovskaya Str.; Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-2166-2574</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Акавова</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Akavova</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Саида Абдулкадыровна Акавова, врач-онколог, зав. Центром</p><p>Центр амбулаторной поликлинической помощи</p><p>117152; Загородное шоссе, д. 18А, стр. 7; Москва</p></bio><bio xml:lang="en"><p>Saida A. Akavova, MD, Oncologist, Head of Center</p><p>Outpatient Care Center</p><p>117152; 18A bldg. 7, Zagorodnoe Shosse; Moscow</p></bio><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3509-9501</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ампилогова</surname><given-names>Д. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Ampilogova</surname><given-names>D. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Диана Михайловна Ампилогова, клинический ординатор</p><p>институт клинической медицины имени Н.В. Склифосовского; кафедра акушерства и гинекологии</p><p>119991;  ул. Большая Пироговская, д. 2, стр. 4; Москва</p></bio><bio xml:lang="en"><p>Diana M. Ampilogova, MD, Clinical Resident</p><p>Department of Obstetrics and Gynecology</p><p>119991; 2 bldg. 4, Bolshaya Pirogovskaya Str.; Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sechenov University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГУ «Федеральный исследовательский центр "Информатика и управление" Российской академии наук»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Research Center "Computer Science and Control", Russian Academy of Sciences</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>АНО ДПО «Московский медико-социальный институт имени Ф.П. Гааза»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow Haass Medical – Social Institute</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет); АНО ДПО «Московский медико-социальный институт имени Ф.П. Гааза»; Институт Превентивной и Социальной Медицины;</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sechenov University; Moscow Haass Medical – Social Institute; Institute for Preventive and Social Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>ГБУЗ «Городская клиническая онкологическая больница № 1 Департамента здравоохранения города Москвы»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>City Clinical Oncological Hospital No. 1, Moscow Healthcare Department</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>18</day><month>05</month><year>2024</year></pub-date><volume>18</volume><issue>2</issue><fpage>218</fpage><lpage>230</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Makatsariya A.D., Bitsadze V.O., Solopova A.G., Gromova O.A., Korabelnikov D.I., Blinov D.V., Khizroeva J.K., Makatsariya N.A., Tretyakova M.V., Akavova S.A., Ampilogova D.M., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Макацария А.Д., Бицадзе В.О., Солопова А.Г., Громова О.А., Корабельников Д.И., Блинов Д.В., Хизроева Д.Х., Макацария Н.А., Третьякова М.В., Акавова С.А., Ампилогова Д.М.</copyright-holder><copyright-holder xml:lang="en">Makatsariya A.D., Bitsadze V.O., Solopova A.G., Gromova O.A., Korabelnikov D.I., Blinov D.V., Khizroeva J.K., Makatsariya N.A., Tretyakova M.V., Akavova S.A., Ampilogova D.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.gynecology.su/jour/article/view/2053">https://www.gynecology.su/jour/article/view/2053</self-uri><abstract><p>   Magnesium is an important cofactor for metabolic reactions involving more than 300 enzymes, regulating a series of fundamental processes, such as myocardial contraction and blood pressure control, glucose regulation, participation in neuromuscular transmission. The prevalence of magnesium deficiency in various cohorts of fertile age women comprises up to 73.8 %. In clinical studies it was demonstrated that magnesium deficiency is associated with diseases and states such as dysmenorrhea, premenstrual syndrome (PMS), polycystic ovary syndrome (POS), climacteric syndrome, osteoporosis, use of combined oral contraceptives (COCs) and menopausal hormone therapy (MHT). Magnesium supplementation in combination with basic therapy can positively affect course and outcome of such pathologies. Magnesium organic salts could be used for countering magnesium deficiency. Among such agents, magnesium citrate has some advantage used in combination with pyridoxine (vitamin B6) providing additional effects. Health care professionals should be guided by the criteria for Mg-containing preparation selection, defined by the Russian Society of Obstetricians and Gynecologists (RSOG).</p></abstract><trans-abstract xml:lang="ru"><p>   Магний является важным кофактором для метаболических реакций с участием свыше 300 ферментов, играющих важную роль в регуляции таких процессов, как сокращение миокарда и контроль артериального давления, регулирование уровня глюкозы, участие в реализации нервно-мышечной проводимости. Распространенность дефицита магния в различных когортах женщин фертильного возраста составляет до 73,8 %. В клинических исследованиях продемонстрировано, что дефицит магния ассоциирован с такими заболеваниями и состояниями, как дисменорея, предменструальный синдром (ПМС), синдром поликистозных яичников (СПКЯ), климактерический синдром, остеопороз, использование комбинированных оральных контрацептивов (КОК) и менопаузальной гормональной терапии (МГТ). Дотация магния в составе комплексной терапии способна позитивно повлиять на их течение и исход. С целью восполнения магниевого дефицита применяются органические соли магния, среди которых рядом преимуществ обладает цитрат магния в сочетании с пиридоксином (витамином B6). Практикующим специалистам следует руководствоваться критериями выбора магнийсодержащего препарата, определенными Пленумом Российского общества акушеров-гинекологов (РОАГ).</p></trans-abstract><kwd-group xml:lang="ru"><kwd>магний</kwd><kwd>дефицит магния</kwd><kwd>дисменорея</kwd><kwd>предменструальный синдром</kwd><kwd>ПМС</kwd><kwd>синдром поликистозных яичников</kwd><kwd>СПКЯ</kwd><kwd>климакс</kwd><kwd>климактерический синдром</kwd><kwd>остеопороз</kwd><kwd>комбинированные оральные контрацептивы</kwd><kwd>КОК</kwd><kwd>менопаузальная гормональная терапия</kwd><kwd>МГТ</kwd><kwd>цитрат магния</kwd><kwd>пиридоксин</kwd><kwd>витамин B6</kwd></kwd-group><kwd-group xml:lang="en"><kwd>magnesium</kwd><kwd>magnesium deficiency</kwd><kwd>dysmenorrhea</kwd><kwd>premenstrual syndrome</kwd><kwd>PMS</kwd><kwd>polycystic ovarian syndrome</kwd><kwd>POS</kwd><kwd>menopause</kwd><kwd>climacteric syndrome</kwd><kwd>osteoporosis</kwd><kwd>oral combined oral contraceptives</kwd><kwd>COCs</kwd><kwd>menopausal hormone therapy</kwd><kwd>MHT</kwd><kwd>magnesium citrate</kwd><kwd>pyridoxine</kwd><kwd>vitamin B6</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Работа выполнена при финансовой поддержке фармацевтической компании Санофи</funding-statement><funding-statement xml:lang="en">The work was financially supported by Sanofi pharmaceutical company</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Grober U., Schmidt J., Kisters K. 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