akusherstvoObstetrics, Gynecology and ReproductionАкушерство, Гинекология и Репродукция2313-73472500-3194IRBIS LLC10.17749/2313-7347/ob.gyn.rep.2024.508akusherstvo-2039Research ArticleREVIEW ARTICLESНАУЧНЫЕ ОБЗОРЫRegarding repeated implantation failures coupled to assisted reproductive technologiesК вопросу о повторных неудачах имплантации при вспомогательных репродуктивных технологияхhttps://orcid.org/0000-0002-5565-607XПервушинаА. А.PervushinaA. A.

Первушина Анна Андреевна – ординатор, врач акушер-гинеколог кафедры акушерства, гинекологии и перинатальной медицины Клинического института детского здоровья имени Н.Ф. Филатова

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Anna A. Pervushina – MD, Obstetrician-Gynecologist, Clinical Resident, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

anya05.08@mail.ruhttps://orcid.org/0000-0002-0725-9686ХизроеваД. Х.KhizroevaJ. Kh.

Хизроева Джамиля Хизриевна – профессор кафедры акушерства, гинекологии и перинатальной медицины Клинического института детского здоровья имени Н.Ф. Филатова

Scopus Author ID: 57194547147

Researcher ID: F-8384-2017

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Jamilya Kh. Khizroeva – MD, Dr Sci Med, Professor, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health

Scopus Author ID: 57194547147

Researcher ID: F-8384-2017

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

https://orcid.org/0000-0001-8404-1042БицадзеВ. О.BitsadzeV. O.

Бицадзе Виктория Омаровна – д.м.н., профессор РАН, профессор кафедры акушерства, гинекологии и перинатальной медицины Клинического института детского здоровья имени Н.Ф. Филатова

Scopus Author ID: 6506003478

Researcher ID: F-8409-2017

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Victoria O. Bitsadze – MD, Dr Sci Med, Professor of RAS, Professor, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health

Scopus Author ID: 6506003478

Researcher ID: F-8409-2017

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский университет)РоссияSechenov UniversityRussian Federation202413052024183401413Copyright © Pervushina A.A., Khizroeva J.K., Bitsadze V.O., 20242024Первушина А.А., Хизроева Д.Х., Бицадзе В.О.Pervushina A.A., Khizroeva J.K., Bitsadze V.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gynecology.su/jour/article/view/2039

Embryo implantation is the first key step in successful pregnancy, but implantation failures remain quite common in patients undergoing assisted reproductive technology (ART) programs. The main known factors of repeated implantation failures (RIF) in patients undergoing ART are unhealthy lifestyle, genetic factor and low gamete quality, uterus pathology, endometriosis and adenomyosis, thrombophilia as well as male factor and embryonic factors. RIF factors and ways to overcome them have received much attention. Despite multiple RIF causes being identified, the underlying etiology and management remain poorly investigated. In clinical practice, studies and interventions providing no clear scientific rationale or convincing evidence on their effectiveness due to the lack of standardized diagnostic and treatment methods that are often used. An effective strategy for treating RIF risk factors is necessary to increase chances for successful pregnancy in ART programs.

Имплантация эмбриона – первый ключевой этап успешной беременности, однако неудачи имплантации в программах вспомогательных репродуктивных технологий (ВРТ) остаются довольно распространенным явлением. Основные известные факторы повторных неудач имплантации (англ. repeated implantation failure, RIF) у пациентов, перенесших ВРТ: нездоровый образ жизни, генетический фактор инизкое качество гамет, патологиисо стороны матки, эндометриоз и аденомиоз, тромбофилия, а также мужской фактор и факторы со стороны эмбриона. Факторам RIF и способам их преодоления уделяется большое внимание исследователей. Однако, несмотря на то, что установлено много возможных причин RIF, многое остается неизвестным относительно этиологии и преодоления этого состояния. В клинической практике нередко применяются исследования и вмешательства без четкого научного обоснования или убедительных доказательств их эффективности из-за отсутствия стандартизации методов диагностики и лечения. Для повышения шансов успешного наступления беременности в программах ВРТ необходима эффективная стратегия лечения, включающая терапию факторов риска RIF каждой конкретной пациентки.

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The authors declare that there are no conflicts of interest present.