<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">akusherstvo</journal-id><journal-title-group><journal-title xml:lang="en">Obstetrics, Gynecology and Reproduction</journal-title><trans-title-group xml:lang="ru"><trans-title>Акушерство, Гинекология и Репродукция</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2313-7347</issn><issn pub-type="epub">2500-3194</issn><publisher><publisher-name>IRBIS LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17749/2313-7347/ob.gyn.rep.2024.487</article-id><article-id custom-type="elpub" pub-id-type="custom">akusherstvo-1959</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LECTURE</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЛЕКЦИЯ</subject></subj-group></article-categories><title-group><article-title>Nutrients and environmental toxicants: effect on placental function and fetal growth</article-title><trans-title-group xml:lang="ru"><trans-title>Нутриенты и токсичные вещества окружающей среды: влияние на функцию плаценты и развитие плода</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4467-240X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ди Ренцо</surname><given-names>Д. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Di Renzo</surname><given-names>G. C.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ди Ренцо Джан Карло – д.м.н., профессор кафедры акушерства и гинекологии Клинического института детского здоровья имени Н.Ф. Филатова; директор; почетный генеральный секретарь Международной федерации акушеров-гинекологов (FIGO). Scopus Author ID: 7103191096. Researcher ID: P-3819-2017.</p><p>119991 Москва, ул. Большая Пироговская, д. 2, стр. 4; Италия, Умбрия, Перуджа, Piazza Italia</p></bio><bio xml:lang="en"><p>Gian C. Di Renzo – MD, Dr Sci Med, Professor, Department of Obstetrics and Gynecology, Filatov Clinical Institute of Children’s Health; Director; Honorary Secretary General of the International Federation of Gynecology and Obstetrics (FIGO), Scopus Author ID: 7103191096. Researcher ID: P-3819-2017.</p><p>2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991;  Italy, Umbria, Perugia, Piazza Italia</p></bio><email xlink:type="simple">giancarlo.direnzo@unipg.it</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет); Центр пренатальной и репродуктивной медицины Университета Перуджи</institution><country>Италия</country></aff><aff xml:lang="en"><institution>Sechenov University; Center for Prenatal and Reproductive Medicine, University of Perugia</institution><country>Italy</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>06</day><month>03</month><year>2024</year></pub-date><volume>18</volume><issue>1</issue><fpage>112</fpage><lpage>124</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Di Renzo G.C., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Ди Ренцо Д.К.</copyright-holder><copyright-holder xml:lang="en">Di Renzo G.C.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.gynecology.su/jour/article/view/1959">https://www.gynecology.su/jour/article/view/1959</self-uri><abstract><p>Understanding the mechanisms by which environmental factors impact reproductive health is crucial for informing public health interventions and policy decisions. By elucidating the pathways through which environmental stressors exert their effects, we can develop targeted strategies to mitigate risks and promote reproductive well-being. In this lecture, we will delve into the latest research findings and emerging trends in the field of environmental reproductive health. By exploring the intricate interplay between environmental exposures and reproductive outcomes, we aim to broaden our understanding of this complex relationship and its implications for human health. Through collaborative efforts across disciplines, we can work towards safeguarding reproductive health for current and future generations.</p></abstract><trans-abstract xml:lang="ru"><p>Понимание механизмов, с помощью которых факторы окружающей среды влияют на репродуктивную систему, имеет решающее значение для обоснования проведения глобальных мероприятий общественного здравоохранения и политических решений, направленных на защиту здоровья населения. Анализ путей воздействия экологических стрессоров необходим для разработки целенаправленных стратегий снижения рисков и обеспечения репродуктивного благополучия. В этой лекции мы углубимся в последние результаты исследований и новые тенденции в области охраны репродуктивного здоровья от негативного влияния окружающей среды. Изучая взаимосвязь между окружающими факторами и показателями репродуктивного здоровья, мы стремимся расширить наше понимание этой сложной системы и ее последствий для организма человека. Благодаря совместным усилиям и междисциплинарному подходу мы можем повысить эффективность превентивных мер для сохранения репродуктивного здоровья нынешнего и будущих поколений.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>нутриенты</kwd><kwd>токсиканты</kwd><kwd>рост плода</kwd><kwd>функция плаценты</kwd></kwd-group><kwd-group xml:lang="en"><kwd>nutrients</kwd><kwd>toxicants</kwd><kwd>fetal growth</kwd><kwd>placental function</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Pomper G.M. On ordinary heroes and American democracy. Routledge, 2016. 328 p.</mixed-citation><mixed-citation xml:lang="en">Pomper G.M. On ordinary heroes and American democracy. Routledge, 2016. 328 p.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Azad M.A.K., Liu G., Bin P. et al. Sulfur-containing amino acid supplementation to gilts from late pregnancy to lactation altered offspring’s intestinal microbiota and plasma metabolites. Appl Microbiol Biotechnol. 2020;104(3):1227–42. https://doi.org/10.1007/s00253-019-10302-6</mixed-citation><mixed-citation xml:lang="en">Azad M.A.K., Liu G., Bin P. et al. Sulfur-containing amino acid supplementation to gilts from late pregnancy to lactation altered offspring’s intestinal microbiota and plasma metabolites. Appl Microbiol Biotechnol. 2020;104(3):1227–42. https://doi.org/10.1007/s00253-019-10302-6</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Tang M., Xu C., Kun Chen K. et al. Hexachlorocyclohexane exposure alters the microbiome of colostrum in Chinese breastfeeding mothers. Environ Pollut. 2019;254(Pt A):112900. https://doi.org/10.1016/j.envpol.2019.07.068.</mixed-citation><mixed-citation xml:lang="en">Tang M., Xu C., Kun Chen K. et al. Hexachlorocyclohexane exposure alters the microbiome of colostrum in Chinese breastfeeding mothers. Environ Pollut. 2019;254(Pt A):112900. https://doi.org/10.1016/j.envpol.2019.07.068.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Di Renzo G.C., Conry J.A., Blake J. et al. International Federation of Gynecology and Obstetrics opinion on reproductive health impacts of exposure to toxic environmental chemicals. Int J Gynecol Obstet. 2015;131(3):219–25. https://doi.org/10.1016/j.ijgo.2015.09.002</mixed-citation><mixed-citation xml:lang="en">Di Renzo G.C., Conry J.A., Blake J. et al. International Federation of Gynecology and Obstetrics opinion on reproductive health impacts of exposure to toxic environmental chemicals. Int J Gynecol Obstet. 2015;131(3):219–25. https://doi.org/10.1016/j.ijgo.2015.09.002</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Gallo M.A., Doull J. History and scope of toxicology. In: Cassarett and Doull’s Toxicology: the basic science of poisons. Ed. Klassen C.D. 5th ed. New York: McGraw-Hill, 1996. 3–11.</mixed-citation><mixed-citation xml:lang="en">Gallo M.A., Doull J. History and scope of toxicology. In: Cassarett and Doull’s Toxicology: the basic science of poisons. Ed. Klassen C.D. 5th ed. New York: McGraw-Hill, 1996. 3–11.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Zoeller R.T., Brown T.R., Doan L.L. et al. Endocrine-disrupting chemicals and public health protection: a statement of principles from The Endocrine Society. Endocrinology. 2012;153(9):4097–110. https://doi.org/10.1210/en.2012-1422</mixed-citation><mixed-citation xml:lang="en">Zoeller R.T., Brown T.R., Doan L.L. et al. Endocrine-disrupting chemicals and public health protection: a statement of principles from The Endocrine Society. Endocrinology. 2012;153(9):4097–110. https://doi.org/10.1210/en.2012-1422</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Ehrlich S., Lambers D., Baccarelli A. et al. Endocrine disruptors: a potential risk factor for gestational diabetes mellitus. Am J Perinatol. 2016;33(13):1313–8. https://doi.org/10.1055/s-0036-1586500</mixed-citation><mixed-citation xml:lang="en">Ehrlich S., Lambers D., Baccarelli A. et al. Endocrine disruptors: a potential risk factor for gestational diabetes mellitus. Am J Perinatol. 2016;33(13):1313–8. https://doi.org/10.1055/s-0036-1586500</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Lathi R.B., Liebert C.A., Brookfield K.F. et al. Conjugated bisphenol A in maternal serum in relation to miscarriage risk. Fertil Steril. 2014;102(1):123–8. https://doi.org/10.1016/j.fertnstert.2014.03.024.</mixed-citation><mixed-citation xml:lang="en">Lathi R.B., Liebert C.A., Brookfield K.F. et al. Conjugated bisphenol A in maternal serum in relation to miscarriage risk. Fertil Steril. 2014;102(1):123–8. https://doi.org/10.1016/j.fertnstert.2014.03.024.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Wang C., Yang L., Wang S. et al. The classic EDCs, phthalate esters and organochlorines, in relation to abnormal sperm quality: a systematic review with meta-analysis. Sci Rep. 2016;6(1):19982. https://doi.org/10.1038/srep19982.</mixed-citation><mixed-citation xml:lang="en">Wang C., Yang L., Wang S. et al. The classic EDCs, phthalate esters and organochlorines, in relation to abnormal sperm quality: a systematic review with meta-analysis. Sci Rep. 2016;6(1):19982. https://doi.org/10.1038/srep19982.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Ferguson K.K., McElrath T.F., Meeker J.D. Environmental phthalate exposure and preterm birth. JAMA Pediatr. 2014;168(1):61–7. https://doi.org/10.1001/jamapediatrics.2013.3699.</mixed-citation><mixed-citation xml:lang="en">Ferguson K.K., McElrath T.F., Meeker J.D. Environmental phthalate exposure and preterm birth. JAMA Pediatr. 2014;168(1):61–7. https://doi.org/10.1001/jamapediatrics.2013.3699.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Chiu Y.H., Williams P.L., Gillman M.W. et al. Association between pesticide residue intake from consumption of fruits and vegetables and pregnancy outcomes among women undergoing infertility treatment with assisted reproductive technology. JAMA Intern Med. 2018;178(1):17–26. https://doi.org/10.1001/jamainternmed.2017.5038.</mixed-citation><mixed-citation xml:lang="en">Chiu Y.H., Williams P.L., Gillman M.W. et al. Association between pesticide residue intake from consumption of fruits and vegetables and pregnancy outcomes among women undergoing infertility treatment with assisted reproductive technology. JAMA Intern Med. 2018;178(1):17–26. https://doi.org/10.1001/jamainternmed.2017.5038.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Birnbaum L.S. When environmental chemicals act like uncontrolled medicine. Trends Endocrinol Metab. 2013;24(7):321–3. https://doi.org/10.1016/j.tem.2012.12.005</mixed-citation><mixed-citation xml:lang="en">Birnbaum L.S. When environmental chemicals act like uncontrolled medicine. Trends Endocrinol Metab. 2013;24(7):321–3. https://doi.org/10.1016/j.tem.2012.12.005</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Bove H., Bongaerts E., Slenders E. et al. Ambient black carbon particles reach the fetal side of human placenta. Nat Commun. 2019;10(1):3866. https://doi.org/10.1038/s41467-019-11654-3</mixed-citation><mixed-citation xml:lang="en">Bove H., Bongaerts E., Slenders E. et al. Ambient black carbon particles reach the fetal side of human placenta. Nat Commun. 2019;10(1):3866. https://doi.org/10.1038/s41467-019-11654-3</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Munić V., Kelnerić Z., Mikac L., Haber V.E. Differences in assessment of macrolide interaction with human MDR1 (ABCB1, P-gp) using rhodamine-123 efflux, ATPase activity and cellular accumulation assays. Eur J Pharm Sci. 2010;41(1):86–95. https://doi.org/10.1016/j.ejps.2010.05.016</mixed-citation><mixed-citation xml:lang="en">Munić V., Kelnerić Z., Mikac L., Haber V.E. Differences in assessment of macrolide interaction with human MDR1 (ABCB1, P-gp) using rhodamine-123 efflux, ATPase activity and cellular accumulation assays. Eur J Pharm Sci. 2010;41(1):86–95. https://doi.org/10.1016/j. ejps.2010.05.016</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Gundacker C., Neesen J., Straka E. et al. Genetics of the human placenta: implications for toxicokinetics. Arch Toxicol. 2016;90(11):2563–81. https://doi.org/10.1007/s00204-016-1816-6</mixed-citation><mixed-citation xml:lang="en">Gundacker C., Neesen J., Straka E. et al. Genetics of the human placenta: implications for toxicokinetics. Arch Toxicol. 2016;90(11):2563–81. https://doi.org/10.1007/s00204-016-1816-6</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Mirabelli M.C., Damon S.A., Beavers S.F., Sircar K.D. Patient–provider discussions about strategies to limit air pollution exposures. Am J Prev Med. 2018;55(2):e49–e52. https://doi.org/10.1016/j.amepre.2018.03.018</mixed-citation><mixed-citation xml:lang="en">Mirabelli M.C., Damon S.A., Beavers S.F., Sircar K.D. Patient–provider discussions about strategies to limit air pollution exposures. Am J Prev Med. 2018;55(2):e49–e52. https://doi.org/10.1016/j.amepre.2018.03.018</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Kinch C.D., Ibhazehiebo K., Jeong J.-H. et al. Low-dose exposure to bisphenol A and replacement bisphenol S induces precocious hypothalamic neurogenesis in embryonic zebrafish. Proc Natl Acad Sci U S A. 2015;112(5):1475–80. https://doi.org/10.1073/pnas.1417731112</mixed-citation><mixed-citation xml:lang="en">Kinch C.D., Ibhazehiebo K., Jeong J.-H. et al. Low-dose exposure to bisphenol A and replacement bisphenol S induces precocious hypothalamic neurogenesis in embryonic zebrafish. Proc Natl Acad Sci U S A. 2015;112(5):1475–80. https://doi.org/10.1073/pnas.1417731112</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Eladak S., Grisin T., Moison D. et al. A new chapter in the bisphenol A story: bisphenol S and bisphenol F are not safe alternatives to this compound. Fertil Steril. 2015;103(1):11–21. https://doi.org/10.1016/j.fertnstert.2014.11.005.</mixed-citation><mixed-citation xml:lang="en">Eladak S., Grisin T., Moison D. et al. A new chapter in the bisphenol A story: bisphenol S and bisphenol F are not safe alternatives to this compound. Fertil Steril. 2015;103(1):11–21. https://doi.org/10.1016/j.fertnstert.2014.11.005.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Hanson M.A., Bardsley A., De-Regil L.M. et al. The International Federation of Gynecology and Obstetrics (FIGO) recommendations on adolescent, preconception, and maternal nutrition: "Think Nutrition First". Int J Gynaecol Obstet. 2015;131 Suppl 4:S213–S253. https://doi.org/10.1016/S0020-7292(15)30034-5</mixed-citation><mixed-citation xml:lang="en">Hanson M.A., Bardsley A., De-Regil L.M. et al. The International Federation of Gynecology and Obstetrics (FIGO) recommendations on adolescent, preconception, and maternal nutrition: "Think Nutrition First". Int J Gynaecol Obstet. 2015;131 Suppl 4:S213–S253. https://doi.org/10.1016/S0020-7292(15)30034-5</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Carson R. Silent spring. New Yorker, 1962.</mixed-citation><mixed-citation xml:lang="en">Carson R. Silent spring. New Yorker, 1962.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
