akusherstvoObstetrics, Gynecology and ReproductionАкушерство, Гинекология и Репродукция2313-73472500-3194IRBIS LLC10.17749/2313-7347/ob.gyn.rep.2024.489akusherstvo-1955Research ArticleREVIEW ARTICLESНАУЧНЫЕ ОБЗОРЫThe role of the microenvironment in tumor growth and spreadingРоль микроокружения в росте и распространении опухолиhttps://orcid.org/0000-0001-8404-1042БицадзеВ. О.BitsadzeV. О.

Бицадзе Виктория Омаровна – д.м.н., профессор РАН, профессор кафедры акушерства, гинекологии и перинатальной медицины Клинического института детского здоровья имени Н.Ф. Филатова. Scopus Author ID: 6506003478. Researcher ID: F-8409-2017

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Victoria O. Bitsadze – MD, Dr Sci Med, Professor of RAS, Professor, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health. Scopus Author ID: 6506003478. Researcher ID: F-8409-2017

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

 

https://orcid.org/0000-0001-7441-2778СлуханчукЕ. В.SlukhanchukЕ. V.

Слуханчук Екатерина Викторовна – к.м.н., доцент кафедры акушерства, гинекологии и перинатальной медицины Клинического института детского здоровья имени Н.Ф. Филатова. Scopus Author ID: 57217824907. WOS Researcher ID: AAW-3812-2021

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Ekaterina V. Slukhanchuk – MD, PhD, Associate Professor, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health. Scopus Author ID: 57217824907. WOS Researcher ID: AAW-3812-2021

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

ekaterina@ginekologhirurg.ruhttps://orcid.org/0000-0002-7456-2386СолоповаА. Г.SolopovaА. G.

Солопова Антонина Григорьевна – д.м.н., профессор кафедры акушерства, гинекологии и перинатальной медицины Клинического института детского здоровья имени Н.Ф. Филатова. Scopus Author ID: 6505479504. Researcher ID: Q-1385-2015

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Antonina G. Solopova – MD, Dr Sci Med, Professor, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children's Health. Scopus Author ID: 6505479504. Researcher ID: Q-1385-2015

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

https://orcid.org/0000-0002-0725-9686ХизроеваД. Х.KhizroevaJ. Kh.

Хизроева Джамиля Хизриевна – д.м.н., профессор кафедры акушерства, гинекологии и перинатальной медицины Клинического института детского здоровья имени Н.Ф. Филатова. Scopus Author ID: 57194547147. Researcher ID: F-8384-2017

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Jamilya Kh. Khizroeva – MD, Dr Sci Med, Professor, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health. Scopus Author ID: 57194547147. Researcher ID: F-8384-2017

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

https://orcid.org/0000-0002-8882-1588ЯкубоваФ. Э.YakubovaF. E.

Якубова Фидан Эльчин кызы – клинический ординатор кафедры акушерства, гинекологии и перинатальной медицины Клинического института детского здоровья имени Н.Ф. Филатова

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Fidan E. Yakubova – MD, Clinical Resident, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children's Health

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

ОруджоваЭ. А.OrudzhovaЕ. А.

Оруджова Эсмира Афлатуновна – зав. центром амбулаторной медицинской помощи женской консультации

123423 Москва, ул. Саляма Адиля, д. 2/44

Esmira A. Orudzhova – MD, Head of Antenatal Outpatient Care Center

2/44 Salyama Adilya Str., Moscow 123423

https://orcid.org/0000-0002-8100-0189ДегтяреваН. Д.DegtyarevaN. D.

Дегтярева Наталья Дмитриевна – студент Клинического института детского здоровья имени Н.Ф. Филатова

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Natalia D. Degtyareva – Student, Filatov Clinical Institute of Children’s Health

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

https://orcid.org/0000-0002-4556-5449ЕгороваЕ. С.EgorovaЕ. S.

Егорова Елена Сергеевна – к.м.н., доцент кафедры акушерства, гинекологии и перинатальной медицины Клинического института детского здоровья имени Н.Ф. Филатова. Scopus Author ID: 5720982859

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Elena S. Egorova – MD, PhD, Associate Professor, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children's Health. Scopus Author ID: 5720982859

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

https://orcid.org/0000-0002-2541-3843МакацарияН. А.MakatsariyaN. А.

Макацария Наталия Александровна – к.м.н., доцент кафедры акушерства, гинекологии и перинатальной медицины Клинического института детского здоровья имени Н.Ф. Филатова. Researcher ID: F-8406-2017

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Nataliya A. Makatsariya – MD, PhD, Associate Professor, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children's Health

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

СамбуроваН. В.SamburovaN. V.

Самбурова Наталья Викторовна – к.м.н., доцент кафедры патофизиологии Института цифрового биодизайна и моделирования живых систем. Scopus Author ID: 57208129705

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Natalia V. Samburova – MD, PhD, Associate Professor, Department of Pathophysiology, Institute of Biodesign and Modeling of Complex Systems. Scopus Author ID: 57208129705

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

https://orcid.org/0000-0003-2976-7128СеровВ. Н.SerovV. N.

Владимир Николаевич Серов – д.м.н., профессор, академик РАН, главный научный сотрудник; президент Российского общества акушеров-гинекологов

117997 Москва, ул. академика Опарина, д. 4

Vladimir N. Serov – MD, Dr Sci Med, Professor, Academician of RАS, Chief Researcher; President of the Russian Society

4 Academika Oparina Str., Moscow 117997

https://orcid.org/0000-0001-6396-4948АшрафянЛ. А.AshrafyanL. А.

Ашрафян Лев Андреевич – д.м.н., профессор, академик РАН, заслуженный врач Российской Федерации, директор Института онкогинекологии и маммологии, зам. директора

117997 Москва, ул. академика Опарина, д. 4

Lev A. Ashrafyan – MD, Dr Sci Med, Professor, Academician of RАS, Honored Doctor of the Russian Federation, Director of the Institute of Oncogynecology and Mammology, Deputy Director

4 Academika Oparina Str., Moscow 117997

https://orcid.org/0000-0003-1070-7336АслановаЗ. Д.AslanovaZ. D.

Асланова Замиля Джамалидиновна – аспирант кафедры акушерства, гинекологии и перинатальной медицины Клинического института детского здоровья имени Н.Ф. Филатова. Scopus Author ID: 57194173388

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Zamilya D. Aslanova – MD, Postgraduate Student, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children's Health

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

https://orcid.org/0000-0003-2136-1641ЛазарчукА. В.LazarchukА. V.

Лазарчук Арина Владимировна – студент Клинического института детского здоровья имени Н.Ф. Филатова

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Arina V. Lazarchuk – Student, Filatov Clinical Institute of Children’s Health

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

https://orcid.org/0009-0004-6250-325XКудрявцеваЕ. С.KudryavtsevaЕ. S.

Кудрявцева Екатерина Сергеевна – студент Клинического института детского здоровья имени Н.Ф. Филатова

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Ekaterina S. Kudryavtseva – Student, Filatov Clinical Institute of Children’s Health

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

https://orcid.org/0000-0003-4768-115XСолоповаА. Е.SolopovaА. Е.

Солопова Алина Евгеньевна – д.м.н., профессор кафедры акушерства, гинекологии и перинатальной медицины Клинического института детского здоровья имени Н.Ф. Филатова; ведущий научный сотрудник отдела лучевой диагностики. Scopus Author ID: 24460923200. Researcher ID: P-8659-2015

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4; 117997 Москва, ул. академика Опарина, д. 4

Alina E. Solopova – MD, Dr Sci Med, Professor, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health; Leading Researcher, Department of Radiation Diagnostics. Scopus Author ID: 24460923200. Researcher ID: P-8659-2015.

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991; 4 Academika Oparina Str., Moscow 117997

 

КапанадзеД. Л.KapanadzeD. L.

Капанадзе Дареджан Левановна – к.м.н., директор

0179 Тбилиси, ул. Узнадзе, д. 78

Daredzhan L. Kapanadze – MD, PhD, Director

78 Uznadze Str., Tbilisi 0179

https://orcid.org/0000-0002-9899-9910ГриЖ.-К.GrisJ.-C.

Гри Жан-Кристоф – д.м.н., профессор кафедры акушерства, гинекологии и перинатальной медицины Клинического института детского здоровья имени Н.Ф. Филатова; профессор гематологии, зав. лабораторией гематологии факультета биологических и фармацевтических наук Университета Монпелье и Университетской больницы Нима; иностранный член РАН. Scopus Author ID: 7005114260. Researcher ID: AAA-2923-2019

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4; 34090 Монпелье, ул. Огюста Бруссоне, д. 163

Jean-Christophe Gris – MD, Dr Sci Med, Professor, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health; Professor of Haematology, Head of the Laboratory of Haematology, Faculty of Biological and Pharmaceutical Sciences Montpellier University and University Hospital of Nîmes; Foreign Member of RAS. Scopus Author ID: 7005114260. Researcher ID: AAA-2923-2019

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

https://orcid.org/0000-0002-9576-1368ЭлаламиИ.ElalamyI.

Элалами Исмаил – д.м.н., профессор кафедры акушерства, гинекологии и перинатальной медицины Клинического института детского здоровья имени Н.Ф. Филатова; профессор; директор гематологии Центра Тромбозов. Scopus Author ID: 7003652413. Researcher ID: AAC-9695-2019.

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4; 75006 Париж, Улица медицинского факультета, д. 12; 75020 Париж, Китайская улица, д. 4

Ismail Elalamy – MD, Dr Sci Med, Professor, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health; Professor; Director of Hematology, Department of Thrombosis Center. Scopus Author ID: 7003652413. Researcher ID: AAC-9695-2019

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991; 12 Rue de l’École de Médecine, Paris 75006; 4 Rue de la Chine, Paris 75020

АйД.AyС.

Aй Джихан – д.м.н., профессор, клиническое подразделение гематологии и гемостазиологии, медицинское отделение I. ScopusAuthor ID: 55356863800.

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4; 11010 Вена, Universitätsring, д. 1 

Cihan Ay – MD, PhD, Professor, Clinical Unit of Hematology and Hemostasiology, Department of Medicine I. Scopus Author ID: 55356863800

10 Universitätsring, Vienna 1010

https://orcid.org/0000-0001-7415-4633МакацарияА. Д.MakatsariyaА. D.

Макацария Александр Давидович – д.м.н., профессор, академик РАН, зав. кафедрой акушерства, гинекологии и перинатальной медицины Клинического института детского здоровья имени Н.Ф. Филатова; вице-президент Российского общества акушеров-гинекологов (РОАГ); Заслуженный врач Российской Федерации; Почетный профессор Венского Университета. Scopus Author ID: 57222220144. Researcher ID: M-5660-2016

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Alexander D. Makatsariya – MD, Dr Sci Med, Academician of RAS, Professor, Head of the Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health; Honorary Doctor of the Russian Federation

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский университет)РоссияSechenov UniversityRussian FederationРодильный дом № 1 – филиал ГБУЗ «Городская клиническая больница № 67 имени Л.А. Ворохобова Департамента здравоохранения города Москвы»РоссияMaternity Hospital No. 1 – Branch of Vorokhobov City Clinical Hospital No. 67 Moscow City Healthcare DepartmentRussian FederationФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова» Министерства здравоохранения Российской ФедерацииРоссияKulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Health Ministry of Russian FederationRussian FederationФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский университет); ФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова» Министерства здравоохранения Российской ФедерацииРоссияSechenov University; Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Health Ministry of Russian FederationRussian FederationЦентр патологии беременности и гемостазаГрузияCenter for Pathology of Pregnancy and HemostasisGeorgiaФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский университет); Университет МонпельеФранцияSechenov University; Montpellier UniversityFranceФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский университет); Медицинский Университет Сорбонны; Госпиталь ТенонФранцияSechenov University; Medicine Sorbonne University; Hospital TenonFranceФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский университет); Венский университетАвстрияUniversity of ViennaAustria20240603202418196111Copyright © Bitsadze V.О., Slukhanchuk Е.V., Solopova А.G., Khizroeva J.K., Yakubova F.E., Orudzhova Е.А., Degtyareva N.D., Egorova Е.S., Makatsariya N.А., Samburova N.V., Serov V.N., Ashrafyan L.А., Aslanova Z.D., Lazarchuk А.V., Kudryavtseva Е.S., Solopova А.Е., Kapanadze D.L., Gris J., Elalamy I., Ay С., Makatsariya А.D., 20242024Бицадзе В.О., Слуханчук Е.В., Солопова А.Г., Хизроева Д.Х., Якубова Ф.Э., Оруджова Э.А., Дегтярева Н.Д., Егорова Е.С., Макацария Н.А., Самбурова Н.В., Серов В.Н., Ашрафян Л.А., Асланова З.Д., Лазарчук А.В., Кудрявцева Е.С., Солопова А.Е., Капанадзе Д.Л., Гри Ж., Элалами И., Ай Д., Макацария А.Д.Bitsadze V.О., Slukhanchuk Е.V., Solopova А.G., Khizroeva J.K., Yakubova F.E., Orudzhova Е.А., Degtyareva N.D., Egorova Е.S., Makatsariya N.А., Samburova N.V., Serov V.N., Ashrafyan L.А., Aslanova Z.D., Lazarchuk А.V., Kudryavtseva Е.S., Solopova А.Е., Kapanadze D.L., Gris J., Elalamy I., Ay С., Makatsariya А.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gynecology.su/jour/article/view/1955Introduction

Introduction. The tumor microenvironment (TME) consisting of non-tumor cells and other components plays a crucial role in cancer development by promoting uncontrolled tumor growth.

Aim

Aim: to detail all the components in TME and their contribution to carcinogenesis by analyzing available publications.

Results

Results. Currently, TME study is of great interest in the medical field. Its crucial role in the tumor initiation, progression, and spreading is emphasized. Several constituents have been identified in TME including cancer-associated fibroblasts, neutrophils, adipocytes, tumor vasculature, lymphocytes, extracellular matrix, dendritic cells, neutrophil extracellular traps, etc. Thromboinflammatory reactions are also considered an important TME element.

Conclusion

Conclusion. TME constituents can serve as new targets for both diagnostics and antitumor therapy.

Введение

Введение. Микроокружение опухоли (МОО) играет одну из самых важных ролей в онкогенезе. В его состав помимо опухолевых клеток входят и неопухолевые клетки и другие компоненты, стимулирующие и способствующие неконтролируемой пролиферации опухоли.

Цель

Цель: в статье подробно изложены все участники МОО и их вклад в онкогенез. Обзор основан на анализе предыдущих исследований по данной проблеме.

Результаты

Результаты. Микроокружению опухоли в настоящее время уделяется большое внимание в литературе. Выделяют его особую роль в инициации, прогрессии опухоли и метастазировании. В исследованиях описаны различные компоненты МОО, такие как рак-ассоциированные фибробласты, нейтрофилы, адипоциты, сосудистая сеть опухоли, лимфоциты, внеклеточный матрикс, дендритные клетки, внеклеточные ловушки и другие. Важную роль отводят участникам реакций тромбовоспаления как неотъемлемой части МОО.

Заключение

Заключение. Компоненты МОО могут выступать в роли новых мишеней как диагностики, так и противоопухолевой терапии.

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The authors declare that there are no conflicts of interest present.