akusherstvoObstetrics, Gynecology and ReproductionАкушерство, Гинекология и Репродукция2313-73472500-3194IRBIS LLC10.17749/2313-7347/ob.gyn.rep.2024.474akusherstvo-1889Research ArticleREVIEW ARTICLESНАУЧНЫЕ ОБЗОРЫThe role of epigenetics in male and female infertilityРоль эпигенетики в мужском и женском бесплодииhttps://orcid.org/0009-0007-2855-5453ЕгороваД. А.EgorovaD. A.

Егорова Диана Андреевна – ассистент

344022 Ростов-на-Дону, Нахичеванский переулок, д. 29

Diana A. Egorova – Assistant

29 Nakhichevansky Lane, Rostov-on-Don, 344022

vkomissiya@inbox.ruhttps://orcid.org/0009-0008-6428-3405ДерезинаВ. В.DerezinaV. V.

Дерезина Виктория Викторовна – ассистент

344022 Ростов-на-Дону, Нахичеванский переулок, д. 29

Victoria V. Derezina – Assistant

29 Nakhichevansky Lane, Rostov-on-Don, 344022

https://orcid.org/0009-0001-8163-0463ЧебанянМ. В.ChebanyanM. V.

Чебанян Михаил Витальевич – ординатор

344022 Ростов-на-Дону, Нахичеванский переулок, д. 29

Mikhail V. Chebanyan – Resident

29 Nakhichevansky Lane, Rostov-on-Don, 344022

https://orcid.org/0009-0002-7461-290XСултоноваМ. Б.SultonovaM. B.

Султонова Милена Бахтикуловна – ординатор

450008 Уфа, ул. Ленина, д. 3

Milena B. Sultоnova – Resident

3 Lenin Str., Ufa 450008

https://orcid.org/0009-0003-6731-0548ИшмуратовТ. В.IshmuratovT. V.

Ишмуратов Тимур Вилюрович – студент

450008 Уфа, ул. Ленина, д. 3

Timur V. Ishmuratov – Student

3 Lenin Str., Ufa 450008

https://orcid.org/0009-0000-8843-0467ГасановМ. М.GasanovM. M.

Гасанов Малик Мурадович – ординатор

344022 Ростов-на-Дону, Нахичеванский переулок, д. 29

Malik M. Gasanov – Resident

29 Nakhichevansky Lane, Rostov-on-Don, 344022

https://orcid.org/0009-0009-6961-4063ЧипчиковаА. З.ChipchikovaA. Z.

Чипчикова Альбина Заурбековна – ординатор

369001 Черкесск, Ставропольская ул., д. 36

Albina Z. Chipchikova – Resident

36 Stavropolskaya Str., Cherkessk 369001

https://orcid.org/0009-0008-6421-0345ПаксилеваС. А.PaksilevaS. A.

Паксилева Софья Андреевна – студент

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Sofya A. Paksileva – Student

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

https://orcid.org/0009-0007-4200-4009МитькинаС. С.MitkinaS. S.

Митькина Сабина Сафаевна – студент

450008 Уфа, ул. Ленина, д. 3

Sabina S. Mitkina – Student

3 Lenin Str., Ufa 450008

https://orcid.org/0000-0003-0345-3489ХамидуллинаР. Р.KhamidullinaR. R.

Хамидуллина Радмила Рафитовна – студент

450008 Уфа, ул. Ленина, д. 3

Radmila R. Khamidullina – Student

3 Lenin Str., Ufa 450008

https://orcid.org/0009-0006-7499-7597КутуеваА. Ш.KutuevaA. Sh.

Кутуева Алина Шамильевна – студент

430005 Саранск, Большевистская ул., д. 68

Alina Sh. Kutueva – Student

68 Bolshevistskaya Str., Saransk 430005

https://orcid.org/0009-0004-5602-6063АникееваА. А.AnikeevaA. A.

Аникеева Арина Андреевна – студент

450008 Уфа, ул. Ленина, д. 3

Arina A. Anikeeva – Student

3 Lenin Str., Ufa 450008

ФГБОУ ВО «Ростовский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияRostov State Medical University, Health Ministry of Russian FederationRussian FederationФГБОУ ВО «Башкирский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияBashkir State Medical University, Health Ministry of Russian FederationRussian FederationФГБОУ ВО «Северо-Кавказская государственная академия»РоссияNorth Caucasus State AcademyRussian FederationФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет)РоссияSechenov UniversityRussian FederationФГБОУ ВО «Национальный исследовательский Мордовский государственный университет имени Н.П. Огарёва»РоссияOgarev National Research Mordovian State UniversityRussian Federation2024250120241816882Copyright © Egorova D.A., Derezina V.V., Chebanyan M.V., Sultonova M.B., Ishmuratov T.V., Gasanov M.M., Chipchikova A.Z., Paksileva S.A., Mitkina S.S., Khamidullina R.R., Kutueva A.S., Anikeeva A.A., 20242024Егорова Д.А., Дерезина В.В., Чебанян М.В., Султонова М.Б., Ишмуратов Т.В., Гасанов М.М., Чипчикова А.З., Паксилева С.А., Митькина С.С., Хамидуллина Р.Р., Кутуева А.Ш., Аникеева А.А.Egorova D.A., Derezina V.V., Chebanyan M.V., Sultonova M.B., Ishmuratov T.V., Gasanov M.M., Chipchikova A.Z., Paksileva S.A., Mitkina S.S., Khamidullina R.R., Kutueva A.S., Anikeeva A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gynecology.su/jour/article/view/1889Introduction

Introduction. Today, infertility is a global problem that affects about 48.5 million married couples worldwide. It has been suggested that epigenetic aberrations are of great importance for reproductive health, as they account for an interactive relationship between genomic landscape, interplay with gene environment and disease phenotype. A new understanding on etiology of complex non-Mendelian disease traits has aroused a growing interest in reproductive epigenetics.

Aim

Aim: to analyze available publications on epigenetic aspects of male and female infertility as well as nutrition-related risk factors.

Materials and Methods

Materials and Methods. There was conducted a search for publications in the electronic databases PubMed, Google Scholar and Library to be selected in accordance with PRISMA recommendations. All relevant articles published before November 2023 were included in this review. As a result of the search, there were extracted 530 publications from PubMed, 57 publications – from eLibrary and 23 publications – from Google Scholar. Duplicates and non-full-text article versions were excluded.

Results

Results. Environmental factors play an important role in generation and maintenance of epigenetic marks. DNA methylation abnormalities can lower human fertility. Altered protamine level may affect epigenetic paternally transmitted DNA information. Long-term infertility is associated with a modified methylome in euploid blastocysts primarily affecting regulation of genomic imprinting. Both excess and deficiency of trace elements are associated with adverse pregnancy outcomes, similarly applied infertility.

Conclusion

Conclusion. Despite that epigenetic mechanisms, genes, nutrition and dietary supplements discussed here affect infertility, while a relevant recommended dose has not yet been determined, it was noted that such parameters may positively influence fertility. However, more comprehensive and longitudinal human studies are required to examine their relationship to male and female reproductive functions.

Введение

Введение. На сегодняшний день бесплодие является глобальной проблемой, которая затрагивает около 48,5 млн супружеских пар во всем мире. Было высказано предположение, что эпигенетические аберрации имеют большое значение для репродуктивного здоровья, поскольку они объясняют интерактивную взаимосвязь между геномным ландшафтом, взаимодействиями с генной средой и фенотипом заболевания. Новое понимание этиологии сложных неменделевских признаков заболеваний вызвало растущий интерес к области репродуктивной эпигенетики.

Цель

Цель: проанализировать литературу, посвященную эпигенетическим аспектам бесплодия, как у мужчин, так и у женщин, а также факторам риска, связанными с питанием. Материалы и методы. Авторы провели поиск публикаций в электронных базах данных PubMed, Google Scholar и еLibrary. Отбор публикаций осуществляли в соответствии с рекомендациями PRISMA. Все соответствующие статьи, опубликованные до ноября 2023 г., были включены в настоящий обзор. В результате поиска было извлечено 530 публикаций из PubMed, 57 публикаций из eLibrary и 23 публикации из Google Scholar. Дубликаты и не полнотекстовые версии статей были исключены.

Результаты

Результаты. Факторы окружающей среды играют важную роль в создании и поддержании эпигенетических меток. Аномалии метилирования ДНК могут снижать фертильность человека. Отклонения, связанные с содержанием протамина, могут влиять на эпигенетическую информацию, передаваемую ДНК отцовской линии. Длительное бесплодие связано с модифицированным метиломом в эуплоидных бластоцистах с особой концентрацией на регуляции геномного импринтинга. Как избыток, так и дефицит микроэлементов связывают с неблагоприятными исходами беременности, то же касается и бесплодия.

Заключение

Заключение. Несмотря на то что эпигенетические механизмы, гены, питание и пищевые добавки, обсуждаемые в этом обзоре, влияют на бесплодие, а рекомендуемая доза еще не определена, было отмечено, что они могут положительно влиять на фертильность. Однако необходимы более всесторонние и лонгитюдные исследования на людях, изучающие их связь с мужскими и женскими репродуктивными функциями.

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The authors declare that there are no conflicts of interest present.