akusherstvoObstetrics, Gynecology and ReproductionАкушерство, Гинекология и Репродукция2313-73472500-3194IRBIS LLC10.17749/2313-7347/ob.gyn.rep.2023.467akusherstvo-1870Research ArticleCLINICAL CASEКЛИНИЧЕСКИЙ СЛУЧАЙRecurrent failure of ART, thrombosis and thrombophiliaПовторные неудачи ЭКО, тромбозы и тромбофилияhttps://orcid.org/0000-0002-0725-9686ХизроеваД. Х.KhizroevaJ. Kh.

Хизроева Джамиля Хизриевна – д.м.н., профессор кафедры акушерства, гинекологии и перинатальной медицины Клинического института детского здоровья имени Н.Ф. Филатова. Scopus Author ID: 57194547147. Researcher ID: F-8384-2017.

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Jamilya Kh. Khizroeva – MD, Dr Sci Med, Professor, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health, Scopus Author ID: 57194547147. Researcher ID: F-8384-2017.

2 bldg. 4, Bolshaya Pirogovskaya Str., 119991

totu1@yandex.ruhttps://orcid.org/0000-0002-4534-2157АнтоноваА. С.AntonovaA. S.

Антонова Александра Сергеевна – ассистент кафедры акушерства, гинекологии и перинатальной медицины Клинического института детского здоровья имени Н.Ф. Филатова. Scopus Author ID: 57215934525.

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Alexandra S. Antonova – MD, Assistant, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health, Scopus Author ID: 57215934525.

2 bldg. 4, Bolshaya Pirogovskaya Str., 119991

https://orcid.org/0000-0002-4556-5449ЕгороваЕ. С.EgorovaE. S.

Егорова Елена Сергеевна – к.м.н., доцент кафедры акушерства, гинекологии и перинатальной медицины Клинического института детского здоровья имени Н.Ф. Филатова. Scopus Author ID: 57209828598.

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Elena S. Egorova – MD, PhD, Associate Professor, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health, Scopus Author ID: 57209828598.

2 bldg. 4, Bolshaya Pirogovskaya Str., 119991

https://orcid.org/0000-0002-2541-3843МакацарияН. А.MakatsariyaN. A.

Макацария Наталия Александровна – к.м.н., доцент кафедры акушерства, гинекологии и перинатальной медицины Клинического института детского здоровья имени Н.Ф. Филатова. Researcher ID: F-8406-2017.

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Nataliya A. Makatsariya – MD, PhD, Associate Professor, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children's Health, Researcher ID: F-8406-2017.

2 bldg. 4, Bolshaya Pirogovskaya Str., 119991

ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет)РоссияSechenov UniversityRussian Federation202304012024176792800Copyright © Khizroeva J.K., Antonova A.S., Egorova E.S., Makatsariya N.A., 20242024Хизроева Д.Х., Антонова А.С., Егорова Е.С., Макацария Н.А.Khizroeva J.K., Antonova A.S., Egorova E.S., Makatsariya N.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gynecology.su/jour/article/view/1870

In recent years, the number of risk factors for thrombosis associated with pregnancy has increased substantially due to the active introduction of new medical technologies not used 30 years ago or because their role in emerging thrombosis has not been studied, e.g., during pregnancy after assisted reproductive technologies (ART) particularly in vitro fertilization (IVF). The risk of venous thromboembolic complications (VTEС) related to ovarian hyperstimulation during ART is often overlooked. We present the case of a 37-year-old woman who developed thrombosis of the right internal jugular vein 3 weeks after embryo transfer within the IVF protocol. Ovarian hyperstimulation during hormonal IVF protocols provokes procoagulant changes in the hemostasis and fibrinolysis system able to result in venous and arterial thrombosis. The localization of VTEС typical to ART is more often located in the internal jugular vein being accompanied by neck pain and edema. Thrombosis risk factors should be assessed in all women in the IVF program, and appropriate thromboprophylaxis should be carried out to all high risk subjects.

За последние годы значительно выросло количество факторов риска тромбозов, связанных с беременностью, что обусловлено активным внедрением новых медицинских технологий, которые еще 30 лет назад не применялись или их роль в возникновении тромбозов не была изучена, например, беременность после вспомогательных репродуктивных технологий (ВРТ), в частности экстракорпорального оплодотворения (ЭКО). Риск венозных тромбоэмболических осложнений (ВТЭО), связанных с гиперстимуляцией яичников при ВРТ, часто упускается из виду. Мы представляем случай 37-летней женщины, у которой развился тромбоз правой внутренней яремной вены через 3 нед после переноса эмбриона в протоколе ЭКО. Гиперстимуляция яичников в процессе гормональных протоколов ЭКО провоцирует прокоагулянтные изменения в системе гемостаза и фибринолиза, что может привести к венозному и артериальному тромбозу. Характерная для ВРТ локализация ВТЭО чаще находится во внутренней яремной вене и сопровождается болью в шее и отеком. Оценка факторов риска тромбоза должна проводиться у всех женщин в программе ЭКО, и соответствующая тромбопрофилактика должна проводиться всем, кто находится в группе высокого риска.

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The authors declare that there are no conflicts of interest present.