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akusherstvo

Obstetrics, Gynecology and Reproduction

Акушерство, Гинекология и Репродукция

2313-73472500-3194

IRBIS LLC

10.17749/2313-7347/ob.gyn.rep.2023.447

akusherstvo-1856

Research Article

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НАУЧНЫЕ ОБЗОРЫ

Clinical significance of determining neutrophil extracellular traps in women with oncogynecological neoplasms

Клиническое значение определения внеклеточных ловушек нейтрофилов у женщин с онкогинекологическими заболеваниями

https://orcid.org/0000-0003-1070-7336

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Асланова Замиля Джамалидиновна – аспирант кафедры акушерства, гинекологии и перинатальной медицины Клинического института детского здоровья имени Н.Ф. Филатова.

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Zamilya D. Aslanova – MD, Postgraduate Student, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children's Health.

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

roseta1091@yandex.ru

https://orcid.org/0000-0002-0725-9686

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Д. Х.

Khizroeva

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Хизроева Джамиля Хизриевна – д.м.н., профессор кафедры акушерства, гинекологии и перинатальной медицины Клинического института детского здоровья имени Н.Ф. Филатова. Scopus Author ID: 57194547147. Researcher ID: F-8384-2017.

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Jamilya Kh. Khizroeva – MD, Dr Sci Med, Professor, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health, Sechenov University, Scopus Author ID: 57194547147. Researcher ID: F-8384-2017.

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

https://orcid.org/0000-0002-7456-2386

Солопова

А. Г.

Solopova

A. G.

Солопова Антонина Григорьевна – д.м.н., профессор кафедры акушерства, гинекологии и перинатальной медицины Клинического института детского здоровья имени Н.Ф. Филатова. Scopus Author ID: 6505479504. Researcher ID: Q-1385-2015.

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Antonina G. Solopova – MD, Dr Sci Med, Professor, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children's Health, Sechenov University, Scopus Author ID: 6505479504. Researcher ID: Q-1385-2015.

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

https://orcid.org/0000-0002-1641-6452

Солодкий

В. А.

Solodkiy

V. A.

Солодкий Владимир Алексеевич – д.м.н., профессор, академик РАН, директор.

117997 Москва, ул. Профсоюзная, д. 86

Vladimir A. Solodkiy – MD, Dr Sci Med, Professor, Academician of RAS, Director, Russian X-Radiology Research Center, Health Ministry of Russian Federation, Russian X-Radiology Research Center.

86 Profsoyuznaya Str., Moscow 117997

https://orcid.org/0000-0002-4509-9281

Воробьев

А. В.

Vorobev

A. V.

Воробьев Александр Викторович – к.м.н., доцент кафедры акушерства, гинекологии и перинатальной медицины Клинического института детского здоровья имени Н.Ф. Филатова. Scopus Author ID: 57191966265. Researcher ID: F-8804-2017.

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Alexander V. Vorobev – MD, PhD, Associate Professor, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health, Sechenov University,. Scopus Author ID: 57191966265. Researcher ID: F-8804-2017.

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

https://orcid.org/0000-0002-3367-9844

Блинов

Д. В.

Blinov

D. V.

Блинов Дмитрий Владиславович – к.м.н., ассистент кафедры спортивной медицины и медицинской реабилитации. Института клинической медицины имени Н.В. Склифосовского ФГАОУ ВО Первый МГМУ имени И.М. Сеченова Министерства здравоохранения РФ (Сеченовский Университет); руководитель по медицинским и научным вопросам, Институт Превентивной и Социальной Медицины; доцент кафедры спортивной, физической и реабилитационной медицины АНО ДПО «Московский медико-социальный институт имени Ф.П. Гааза». Scopus Author ID: 6701744871. Researcher ID: E-8906-2017. RSCI: 9779-8290.

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4; 127006 Москва, ул. Садовая-Триумфальная, д. 4–10; 123056 Москва, 2-я Брестская ул., д. 5, с. 1–1а

Dmitry V. Blinov – MD, PhD, MBA, Assistant, Department of Sports Medicine and Medical Rehabilitation, Sklifosovsky Institute of Clinical Medicine; Head of Medical and Scientific Affairs; Associate Professor, Department of Sports, Physical and Rehabilitation Medicine. Scopus Author ID: 6701744871. Researcher ID: E-8906-2017. RSCI: 9779-8290.

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991; 4–10 Sadovaya-Triumfalnaya Str., Moscow 127006; 5 bldg. 1–1a, 2-ya Brestskaya Str., Moscow 123056

https://orcid.org/0009-0006-8906-0289

Асланова

М. Д.

Aslanova

M. D.

Асланова Марина Джамалидиновна – врач-эндокринолог отделения радионуклидной диагностики.

117997 Москва, ул. Профсоюзная, д. 86

Marina D. Aslanova – Endocrinologist, Department of Radionuclide Diagnostics.

86 Profsoyuznaya Str., Moscow 117997

https://orcid.org/0000-0003-2245-2852

Накаидзе

И. А.

Nakaidze

I. A.

Накаидзе Инга Александровна – аспирант кафедры акушерства, гинекологии и перинатальной медицины Клинического института детского здоровья имени Н.Ф. Филатова.

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Inga A. Nakaidze – MD, Postgraduate Student, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health.

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

https://orcid.org/0000-0002-9899-9910

Гри

Ж.-К.

Gris

J.-C.

Гри Жан-Кристоф – д.м.н., профессор кафедры акушерства, гинекологии и перинатальной медицины Клинического института детского здоровья имени Н.Ф. Филатова ; профессор гематологии, зав. лабораторией гематологии факультета биологических и фармацевтических наук Университета Монпелье и Университетской больницы Нима; иностранный член РАН. Scopus Author ID: 7005114260. Researcher ID: AAA-2923-2019.

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4; 34090 Монпелье, ул. Огюста Бруссоне, д. 163

Jean-Christophe Gris – MD, Dr Sci Med, Professor, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health, Sechenov University; Professor of Haematology, Head of the Laboratory of Haematology, Faculty of Biological and Pharmaceutical Sciences, Montpellier University and University Hospital of Nîmes; Foreign Member of RAS. Scopus Author ID: 7005114260. Researcher ID: AAA-2923-2019.

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991; 163 Rue Auguste Broussonnet, Montpellier 34090

https://orcid.org/0000-0002-9576-1368

Элалами

И.

Elalamy

Элалами Исмаил – д.м.н., профессор кафедры акушерства, гинекологии и перинатальной медицины Клинического института детского здоровья имени Н.Ф. Филатова; профессор медицинского Университета Сорбонны; директор гематологии Центра Тромбозов, Госпиталь Тенон, Scopus Author ID: 7003652413. Researcher ID: AAC-9695-2019.

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4; 75006 Париж, Улица медицинского факультета, д. 12; 75020 Париж, Китайская улица, д. 4

Ismail Elalamy – MD, Dr Sci Med, Professor, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health, Sechenov University; Professor, Medicine Sorbonne University; Director of Hematology, Department of Thrombosis Center, Hospital Tenon. Scopus Author ID: 7003652413. Researcher ID: AAC-9695-2019.

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991; 12 Rue de l’École de Médecine, Paris 75006; 4 Rue de la Chine, Paris 75020

https://orcid.org/0000-0001-7415-4633

Макацария

А. Д.

Makatsariya

A. D.

Макацария Александр Давидович – д.м.н., профессор, академик РАН, зав. кафедрой акушерства, гинекологии и перинатальной медицины Клинического института детского здоровья имени Н.Ф. Филатова; вице-президент Российского общества акушеров-гинекологов (РОАГ); Заслуженный врач Российской Федерации; Почетный профессор Венского Университета. Scopus Author ID: 57222220144. Researcher ID: M-5660-2016.

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Alexander D. Makatsariya – MD, Dr Sci Med, Academician of RAS, Professor, Head of the Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health; Vice-President of the Russian Society of Obstetricians and Gynecologists (RSOG); Honorary Doctor of the Russian Federation; Emeritus Professor of the University of Vienna.

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский университет)РоссияSechenov UniversityRussian Federation

ФГБУ «Российский научный центр рентгенорадиологии» Министерства здравоохранения Российской ФедерацииРоссияRussian X-Radiology Research Center, Health Ministry of Russian FederationRussian Federation

ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский университет); Институт Превентивной и Социальной Медицины; АНО ДПО «Московский медико-социальный институт имени Ф.П. Гааза»РоссияSechenov University; Institute for Preventive and Social Medicine; Moscow Haass Medical – Social InstituteRussian Federation

ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский университет); Университет МонпельеФранцияSechenov University; University of MontpellierFrance

ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский университет); Медицинский Университет Сорбонны; Госпиталь ТенонФранцияSechenov University; Medicine Sorbonne University; Hospital TenonFrance

2023

02012024

176751768

2024

Асланова З.Д., Хизроева Д.Х., Солопова А.Г., Солодкий В.А., Воробьев А.В., Блинов Д.В., Асланова М.Д., Накаидзе И.А., Гри Ж., Элалами И., Макацария А.Д.

Aslanova Z.D., Khizroeva J.K., Solopova A.G., Solodkiy V.A., Vorobev A.V., Blinov D.V., Aslanova M.D., Nakaidze I.A., Gris J., Elalamy I., Makatsariya A.D.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.gynecology.su/jour/article/view/1856

The formation of neutrophil extracellular traps (NETs), described first in 2004 as a previously unknown neutrophil strategy for combating microbes, has been attracting a growing interest in research community. NETs play a key role in inflammation and infection exploiting effector functions such as degranulation, phagocytosis as well as production of reactive oxygen species (ROS). NETs play a crucial role in defense against systemic infections. Additionally NETs involved in inflammation, and in the pathogenesis of non-infectious diseases, such as autoimmune diseases and cancer.

Образование внеклеточных ловушек нейтрофилов (англ. neutrophil extracellular traps, NETs), впервые описанное в 2004 г. как ранее неизвестная стратегия нейтрофилов для борьбы с микробами, привлекает растущий интерес в исследовательском сообществе. NETs выполняют ключевую роль в воспалении и инфекции, где они используют такие эффекторные функции, как дегрануляция, фагоцитоз, образование активных форм кислорода (англ. reactive oxygen species, ROS). NETs играют решающую роль в реализации защитно-приспособительных процессов, таких как воспаление, и патогенезе неинфекционных заболеваний, таких как аутоиммунные заболевания и рак.

внеклеточные ловушки нейтрофиловNETsнетозмиелопероксидазацитруллинированный гистон H3раконкологические заболевания

neutrophil extracellular trapsNETsNETosismyeloperoxidasecitrullinated histone H3canceroncological diseases

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The authors declare that there are no conflicts of interest present.