akusherstvoObstetrics, Gynecology and ReproductionАкушерство, Гинекология и Репродукция2313-73472500-3194IRBIS LLC10.17749/2313-7347/ob.gyn.rep.2023.442akusherstvo-1767Research ArticleREVIEW ARTICLESНАУЧНЫЕ ОБЗОРЫRegarding the prospects of using Lactobacillus-based probiotics, D-mannose and cranberry extracts in therapy of urinary tract infectionsО перспективах применения лактобактериальных пробиотиков, D-маннозы и экстрактов клюквы в терапии инфекций мочевыводящих путейhttps://orcid.org/0000-0002-7663-710XГромоваО. А.GromovaO. A.

Громова Ольга Алексеевна – д.м.н., профессор, ведущий научный сотрудник

119333 Москва, ул. Вавилова, д. 44, корп. 2

Olga A. Gromova – MD, Dr Sci Med, Professor, Leading Researcher

44 bldg. 2, Vavilova Str., Moscow 119333

unesco.gromova@gmail.comhttps://orcid.org/0000-0002-2659-7998ТоршинИ. Ю.TorshinI. Yu.

Торшин Иван Юрьевич – к.ф-м.н., к.х.н., старший научный сотрудник 

Scopus Author ID: 7003300274. Author ID: 54104WOS ID: C-7683-2018

119333 Москва, ул. Вавилова, д. 44, корп. 2

Ivan Yu. Torshin – PhD in Applied Mathematics, PhD in Chemistry, Senior Researcher

Scopus Author ID: 7003300274 Author ID: 54104WOS ID: C-7683-2018

44 bldg. 2, Vavilova Str., Moscow 119333

ФГУ «Федеральный исследовательский центр "Информатика и управление" Российской академии наук»РоссияFederal Research Center "Computer Science and Control", Russian Academy of SciencesRussian Federation202306092023174485499Copyright © Gromova O.A., Torshin I.Y., 20232023Громова О.А., Торшин И.Ю.Gromova O.A., Torshin I.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gynecology.su/jour/article/view/1767

Antibiotics are most often used to combat urinary tract infections (UTIs). Taking into account the side effects related to antibiotic therapy, existing antibiotic-resistant strains of uropathogens, as well as the low effectiveness of the vast majority of antibiotics against bacterial agglomerations (biofilms), a search for alternative approaches to treat UTIs is highly relevant. One of the important in such search is presented by use of nutraceuticals – D-mannose (prevents interaction between pathogenic E. coli strains and the urothelium, destroys bacterial biofilms), Lactobacilli (prevents formation of bacterial pathogen biofilms, normalizes human microbiome, alleviates inflammation) and standardized cranberry extracts (inhibits uropathogen adhesion, exerts anti-inflammatory action). The results from basic and clinical studies suggest not only about high safety of such pharmaconutraceutical support of UTIs therapy, but also the effectiveness of separate and combined use of such nutraceuticals comparable to that of antibiotics, especially in treatment of uncomplicated UTIs forms

Для борьбы с инфекциями мочевыводящих путей (ИМП) чаще всего используются антибиотики. Принимая во внимание побочные эффекты антибиотикотерапии, существование штаммов уропатогенов, резистентных к антибиотикам, и низкую эффективность подавляющего большинства антибиотиков по отношению к бактериальным агломерациям (биоплёнкам), весьма актуален поиск альтернативных подходов к терапии ИМП. Одним из важных направлений этого поиска является использование нутрицевтиков – D-маннозы (предотвращает взаимодействие патогенных штаммов E. coli с уротелием, разрушает биоплёнки), лактобактерий (препятствуют образованию биоплёнок бактериальных патогенов, нормализуют микробиом человека, снижают воспаление) и стандартизированных экстрактов клюквы (нарушают адгезию уропатогенов, оказывают противовоспалительное действие). Результаты фундаментальных и клинических исследований указывают не только на высокую безопасность такого фармаконутрицевтического сопровождения терапии ИМП, но и на эффективность раздельного и сочетанного приёма этих нутрицевтиков, сопоставимую с эффективностью антибиотиков, особенно при лечении неосложнённых форм ИМП.

 

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The authors declare that there are no conflicts of interest present.