akusherstvoObstetrics, Gynecology and ReproductionАкушерство, Гинекология и Репродукция2313-73472500-3194IRBIS LLC10.17749/2313-7347/ob.gyn.rep.2023.431akusherstvo-1761Research ArticleОRIGINAL ARTICLESОРИГИНАЛЬНЫЕ СТАТЬИHomocysteine, cancer and oncothrombosisГомоцистеин, рак и онкотромбозыhttps://orcid.org/0000-0001-8404-1042БицадзеВ. О.BitsadzeV. O.

Бицадзе Виктория Омаровна – д.м.н., профессор РАН, профессор кафедры акушерства, гинекологии и перинатальной медицины Клинического института детского здоровья имени Н.Ф. Филатова 

Scopus Author ID: 6506003478.Researcher ID: F-8409-2017.

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Victoria O. Bitsadze – MD, Dr Sci Med, Professor of RAS, Professor, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health

Scopus Author ID: 6506003478. Researcher ID: F-84092017

https://orcid.org/0000-0001-7441-2778СлуханчукЕ. В.SlukhanchukE. V.

Слуханчук Екатерина Викторовна – к.м.н., доцент кафедры акушерства, гинекологии и перинатальной медицины Клинического института детского здоровья имени Н.Ф. Филатова 

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Ekaterina V. Slukhanchuk – MD, PhD, Associate Professor, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Healt

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

ekaterina@ginekologhirurg.ruhttps://orcid.org/0000-0002-7456-2386СолоповаА. Г.SolopovaA. G.

Солопова Антонина Григорьевна – д.м.н., профессор кафедры акушерства, гинекологии и перинатальной медицины Клинического института детского здоровья имени Н.Ф. Филатова 

Scopus Author ID: 6505479504.Researcher ID: Q-1385-

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Antonina G. Solopova – MD, Dr Sci Med, Professor, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children's Health

Scopus Author ID: 6505479504. Researcher ID: Q-1385-2015

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

https://orcid.org/0000-0002-0725-9686ХизроеваД. Х.KhizroevaJ. Kh.

Хизроева Джамиля Хизриевна – д.м.н., профессор кафедры акушерства, гинекологии и перинатальной медицины Клинического института детского здоровья имени Н.Ф. Филатова 

Scopus Author ID: 57194547147.Researcher ID: F-8384-2017

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Jamilya Kh. Khizroeva – MD, Dr Sci Med, Professor, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health

Scopus Author ID: 57194547147. Researcher ID: F-8384-2017

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

https://orcid.org/0000-0003-0226-9276ЩербаковД. В.ShcherbakovD. V.

Щербаков Денис Викторович – к.м.н., доцент кафедры общей гигиены института общественного здоровья имени Ф.Ф. Эрисмана 

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Denis V. Shcherbakov – MD, PhD, Associate Professor, Department of General Hygiene, Erisman Institute of Public Health

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

https://orcid.org/0000-0002-8882-1588ЯкубоваФ. Э.YakubovaF. E.

Якубова Фидан Эльчин кызы – клинический ординатор кафедры акушерства, гинекологии и перинатальной медицины Клинического института детского здоровья имени Н.Ф. Филатова 

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Fidan E. Yakubova – MD, Clinical Resident, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children's Health

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

https://orcid.org/0000-0002-9899-9910ГриЖ.-К.GrisJ.-C.

Гри Жан-Кристоф – д.м.н., профессор кафедры акушерства, гинекологии и перинатальной медицины Клинического института детского здоровья имени Н.Ф. Филатова Ф Сеченовского университета; профессор гематологии, зав. лабораторией гематологии факультета биологических и фармацевтических наук Университета Монпелье и Университетской больницы Нима, Франция; иностранный член РАН

Scopus Author ID: 7005114260.Researcher ID: AAA-2923-2019

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4; Франция, 34090 Монпелье, ул. Огюста Бруссоне, д. 163

Jean-Christophe Gris – MD, Dr Sci Med, Professor, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health, Sechenov University; Professor of Haematology, Head of the Laboratory of Haematology, Faculty of Biological and Pharmaceutical Sciences, Montpellier University and University Hospital of Nîmes, France; Foreign Member of RAS

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991, Russia; 163 Rue Auguste Broussonnet, Montpellier 34090, France

https://orcid.org/0000-0002-9576-1368ЭлаламиИ.ElalamyI.

Элалами Исмаил – д.м.н., профессор кафедры акушерства, гинекологии и перинатальной медицины Клинического института детского здоровья имени Н.Ф. Филатова Сеченовского Университета,; профессор медицинского Университета Сорбонны; директор гематологии Центра Тромбозов, Госпиталь Тенон

Scopus Author ID: 7003652413.Researcher ID: AAC-9695-2019

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4; Франция, 75006 Париж, Улица медицинского факультета, д. 12; Франция, 75020 Париж, Китайская улица, д. 4

Ismail Elalamy – MD, Dr Sci Med, Professor, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health, Sechenov University; Professor, Medicine Sorbonne University, Paris, France; Director of Hematology, Department of Thrombosis Center, Hospital Tenon

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991, Russia; 12 Rue de l’École de Médecine, Paris 75006, France; 4 Rue de la Chine, Paris 75020, France

https://orcid.org/0000-0002-8100-0189ДегтяреваН. Д.DegtyarevaN. D.

Дегтярева Наталья Дмитриевна – студент 5-го курса Клинического института детского здоровья имени Н.Ф. Филатова 

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Natalia D. Degtyareva – 5th year Student, Filatov Clinical Institute of Children’s Health

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

https://orcid.org/0000-0003-2136-1641ЛазарчукА. В.LazarchukA. V.

Лазарчук Арина Владимировна – студент 5-го курса Клинического института детского здоровья имени Н.Ф. Филатова 

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Arina V. Lazarchuk – 5th year Student, Filatov Clinical Institute of Children’s Health

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

https://orcid.org/0009-0005-1689-7240ГилеваМ. А.GilevaM. A.

Гилева Мария Алексеевна – клинический ординатор кафедры акушерства, гинекологии и перинатальной медицины Клинического института детского здоровья имени Н.Ф. Филатова 

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Maria A. Gileva – MD, Clinical Resident, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children's Health

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

https://orcid.org/0000-0002-4564-8439СамбуроваН. В.SamburovaN. V.

Самбурова Наталья Викторовна – к.м.н., доцент кафедры патофизиологии Института биодизайна и моделирования сложных систем 

Scopus Author ID: 57208129705

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Natalia V. Samburova – MD, PhD, Associate Professor, Department of Pathophysiology, Institute of Biodesign and Modeling of Complex Systems

Scopus Author ID: 57208129705

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

https://orcid.org/0000-0003-1070-7336АслановаЗ. Д.AslanovaZ. D.

Асланова Замиля Джамалидиновна – аспирант кафедры акушерства, гинекологии и перинатальной медицины Клинического института детского здоровья имени Н.Ф. Филатова 

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Zamilya D. Aslanova – MD, Postgraduate Student, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children's Health

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

https://orcid.org/0000-0002-3367-9844БлиновД. В.BlinovD. V.

Блинов Дмитрий Владиславович – к.м.н., ассистент кафедры спортивной медицины и медицинской реабилитации Института клинической медицины имени Н.В. Склифосовского  Сеченовского Университета; руководитель по медицинским и научным вопросам, Институт Превентивной и Социальной Медицины; доцент кафедры спортивной, физической и реабилитационной медицины АНО ДПО «Московский медико-социальный институт имени Ф.П. Гааза»

Scopus Author ID: 6701744871.Researcher ID: E-8906-2017

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4; 127006 Москва, ул. Садовая-Триумфальная, д. 4–10; 123056 Москва, 2-я Брестская ул., д. 5, с. 1–1а;

 

 

Dmitry V. Blinov – MD, PhD, MBA, Assistant, Department of Sports Medicine and Medical Rehabilitation, Sklifosovsky Institute of Clinical Medicine, Sechenov University; Head of Medical and Scientific Affairs, Institute for Preventive and Social Medicine; Associate Professor, Department of Sports, Physical and Rehabilitation Medicine, Moscow Haass Medical – Social Institute

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991;4–10 Sadovaya-Triumfalnaya Str., Moscow 127006; 2/44 Salyama Adilya Str., Moscow 123423

https://orcid.org/0000-0002-9783-1796ШкодаА. С.ShkodaA. S.

Шкода Андрей Сергеевич – д.м.н., профессор, главный врач 

123423 Москва, ул. Саляма Адиля, д. 2/44

Andrey S. Shkoda – MD, Dr Sci Med, Professor, Chief Physician

2/44 Salyama Adilya Str., Moscow 123423

https://orcid.org/0000-0001-7415-4633МакацарияА. Д.MakatsariyaA. D.

Макацария Александр Давидович – д.м.н., профессор, академик РАН, зав. кафедрой акушерства, гинекологии и перинатальной медицины Клинического института детского здоровья имени Н.Ф. Филатова  Сеченовского Университета; вице-президент Российского общества акушеров-гинекологов (РОАГ); Заслуженный врач Российской Федерации; Почетный профессор Венского Университета

Scopus Author ID: 57222220144.Researcher ID: M-5660-2016

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Alexander D. Makatsariya – MD, Dr Sci Med, Academician of RAS, Professor, Head of the Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health, Sechenov University; Vice-President of the Russian Society of Obstetricians and Gynecologists (RSOG); Honorary Doctor of the Russian Federation; Emeritus Professor of the University of Vienna

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский университет)РоссияSechenov UniversityRussian FederationФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский университет); Университет МонпельеРоссияSechenov University; University of MontpellierRussian FederationФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский университет); Медицинский Университет Сорбонны; Госпиталь ТенонРоссияSechenov University; Medicine Sorbonne University; Hospital TenonRussian FederationФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский университет); Институт Превентивной и Социальной Медицины; АНО ДПО «Московский медико-социальный институт имени Ф.П. Гааза»;РоссияSechenov University; Institute for Preventive and Social Medicine; Moscow Haass Medical – Social InstituteRussian FederationГБУЗ «Городская клиническая больница № 67 имени Л.А. Ворохобова Департамента здравоохранения города Москвы»РоссияVorokhobov City Clinical Hospital № 67, Moscow Healthcare DepartmentRussian Federation202305092023174390401Copyright © Bitsadze V.O., Slukhanchuk E.V., Solopova A.G., Khizroeva J.K., Shcherbakov D.V., Yakubova F.E., Gris J., Elalamy I., Degtyareva N.D., Lazarchuk A.V., Gileva M.A., Samburova N.V., Aslanova Z.D., Blinov D.V., Shkoda A.S., Makatsariya A.D., 20232023Бицадзе В.О., Слуханчук Е.В., Солопова А.Г., Хизроева Д.Х., Щербаков Д.В., Якубова Ф.Э., Гри Ж., Элалами И., Дегтярева Н.Д., Лазарчук А.В., Гилева М.А., Самбурова Н.В., Асланова З.Д., Блинов Д.В., Шкода А.С., Макацария А.Д.Bitsadze V.O., Slukhanchuk E.V., Solopova A.G., Khizroeva J.K., Shcherbakov D.V., Yakubova F.E., Gris J., Elalamy I., Degtyareva N.D., Lazarchuk A.V., Gileva M.A., Samburova N.V., Aslanova Z.D., Blinov D.V., Shkoda A.S., Makatsariya A.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gynecology.su/jour/article/view/1761Introduction

Introduction. Hyperhomocysteinemia (HHC) is one of the arms in the pathogenesis of thrombotic complications in female cancer patients.

Aim

Aim: to assess an HHC-related impact to developing thrombotic complications in patients with malignant neoplasms of the female genital organs and breast cancer.

Materials and Methods

Materials and Methods. There were retrospectively evaluated the data collected from 236 patients: with ovarian tumors (n = 63), cervical cancer (n = 51), breast tumors (n = 64), malignant neoplasms of the uterine body (n = 58). The control group consisted of 50 women without malignant neoplasms. The analysis of homocysteine (HC) concentration, the frequency of polymorphisms of the genes encoding folate cycle enzymes MTHFR C677T, MTHFR A1298C, MTRR A66G, MTR A2756G as well as the rate of thrombotic complications was carried out. A risk of blood HC level-related thrombotic complications was assessed.

Results

Results. Plasma HC concentration comprised ≥ 22 μmol/l in 30.5 % of patients. Thrombotic complications within one year after discharge from the hospital were developed in 15.3 % cases. The risk of thrombotic complications turned out to be higher in patients with elevated plasma HC level (≥ 22 μmol/l) (odds ratio = 2.99; 95 % confidence interval = 1.11–8.08). No significantly increased prevalence of polymorphisms in the genes encoding folate cycle enzymes among female cancer patients was detected.

Conclusion

Conclusion. Monitoring HC level in female cancer patients contributes separately to predict a likelihood of thrombotic complications. Prescribing drugs that reduce HC level (folic acid) and monitoring its concentration in female cancer patients during therapy, including chemotherapy, can potentially lower an incidence of thrombotic complications.

Введение

Введение. Гипергомоцистеинемия (ГГЦ) является одним из звеньев патогенеза тромботических осложнений у онкогинекологических пациенток.

Цель

Цель: оценка вклада ГГЦ в развитие тромботических осложнений у пациенток со злокачественными новообразованиями женских половых органов и молочной железы.

Материалы и методы

Материалы и методы. Выполнена ретроспективная оценка данных 236 пациенток: с опухолями яичников (n = 63), раком шейки матки (n = 51), опухолями молочных желез (n = 64), злокачественными новообразованиями тела матки (n = 58). Контрольную группу составили 50 женщин без злокачественных новообразований. Проведен анализ концентрации гомоцистеина (ГЦ), частоты полиморфизмов генов ферментов фолатного цикла MTHFR C677T, MTHFR A1298C, MTRR A66G, MTR A2756G, частоты тромботических осложнений. Проведена оценка риска тромботических осложнений в зависимости от концентрации ГЦ в крови.

Результаты

Результаты. Концентрация ГЦ в плазме крови составила ≥ 22 мкмоль/л у 30,5 % пациенток. Тромботические осложнения в течение 1 года после выписки из стационара развились у 15,3 %. Риск тромботических осложнений оказался выше у пациенток с высоким уровнем ГЦ (≥ 22 мкмоль/л) в плазме крови (отношение шансов = 2,99; 95 % доверительный интервал = 1,11–8,08). Достоверного увеличения частоты встречаемости полиморфизмов генов ферментов фолатного цикла среди онкогинекологических пациенток выявлено не было.

Заключение

Заключение. Мониторинг содержания ГЦ у онкогинекологических пациенток вносит свой вклад в прогнозирование вероятности тромботических осложнений. Назначение препаратов, снижающих уровень ГЦ (фолиевая кислота), и проведение мониторинга его концентрации у онкогинекологических пациенток на фоне терапии, в том числе и химиотерапии, потенциально способно снизить частоту развития тромботических осложнений.

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The authors declare that there are no conflicts of interest present.