akusherstvoObstetrics, Gynecology and ReproductionАкушерство, Гинекология и Репродукция2313-73472500-3194IRBIS LLC10.17749/2070-4968.2015.9.3.045-052akusherstvo-172Research ArticleREVIEW ARTICLEНАУЧНЫЙ ОБЗОРPATHOGENETIC ASPECTS OF ATHEROTHOMBOTIC RISK IN OBESITY AND THROMBOPHILIAПАТОГЕНЕТИЧЕСКИЕ АСПЕКТЫ АТЕРОТРОМБОТИЧЕСКОГО РИСКА ПРИ ОЖИРЕНИИ И ТРОМБОФИЛИИХромылевА. В.KhromylevA. V.
аспирант кафедры акушерства и гинекологии
graduate student of the Department of Obstetrics and Gynecology
khromilev@mail.ruГБОУ ВПО «Первый МГМУ имени И.М. Сеченова» Минздрава России, МоскваРоссияFirst Moscow State Medical Sechenov UniversityRussian Federation201519062016934552Copyright © Khromylev A.V., 20162016Хромылев А.В.Khromylev A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gynecology.su/jour/article/view/172Метаболический синдроможирениеатеросклерозтромботические осложнениятромбозтромбофилияMetabolic syndromeobesitythromboembolic complicationsthrombosisthrombophiliaReferencesМакацария А.Д., Бицадзе В.О. Антифосфо- липидный синдром – иммунная тромбофи- лия в акушерстве и гинекологии. М. 2013; 485с.Makatsariya A.D., Bitsadze V.O. Antiphospholipid syndrome – the immune thrombophilia in obstetrics and gynecology [Antifosfolipidnyi sindrom – immunnaya trombofiliya v akusherstve i ginekologii (in Russian)]. Moscow. 2013; 485 s.Макацария А.Д., Белобородова Е.В., Байму- радова С.М., Бицадзе В.О. Гепергомоцистеи- немия и осложнения беременности. М. 2007; 216 с.Makatsariya A.D., Beloborodova E.V., Baimuradova S.M., Bitsadze V.O. Gepergomotsisteinemiya and pregnancy complications [Gepergomotsisteinemiya i oslozhneniya beremennosti (in Russian)]. Moscow. 2007; 216 s.Ageno W., Becattini C., Brighton T. et al. Cardiovascular risk factors and venous thromboembolism: a meta-analysis. Circulation. 2008; 117: 93-102.Ageno W., Becattini C., Brighton T. et al. Cardiovascular risk factors and venous thromboembolism: a meta-analysis. Circulation. 2008; 117: 93-102.Aguilera C.M., Ramirez-Tortosa M.C., Mesa M.D., Gil A. Protective effect of monounsaturated and polyunsaturated fatty acids on the development of cardiovascular disease. Nutr Hosp. 2001; 16: 78-91.Aguilera C.M., Ramirez-Tortosa M.C., Mesa M.D., Gil A. Protective effect of monounsaturated and polyunsaturated fatty acids on the development of cardiovascular disease. Nutr Hosp. 2001; 16: 78-91.Allman-Farinelli M.A. Obesity and venous thrombosis: a review. Semin Thromb Hemost. 2011; 37: 903-907.Allman-Farinelli M.A. Obesity and venous thrombosis: a review. Semin Thromb Hemost. 2011; 37: 903-907.Anfossi G., Russo I., Trovati M. Platelet dysfunction in central obesity. Nutr Metab Cardiovasc Dis. 2009; 19: 440-449.Anfossi G., Russo I., Trovati M. Platelet dysfunction in central obesity. Nutr Metab Cardiovasc Dis. 2009; 19: 440-449.Aubert H., Frere C., Aillaud M.F. et al. Weak and non-independent association between plasma TAFI antigen levels and the insulin resistance syndrome. J Thromb Haemost. 2003; 1: 791-797.Aubert H., Frere C., Aillaud M.F. et al. Weak and non-independent association between plasma TAFI antigen levels and the insulin resistance syndrome. J Thromb Haemost. 2003; 1: 791-797.Badimon L., Hernandez Vera R., Vilahur G. Atherothrombotic risk in obesity. Hamostaseologie. 2013; 33: 259-68.Badimon L., Hernandez Vera R., Vilahur G. Atherothrombotic risk in obesity. Hamostaseologie. 2013; 33: 259-68.Badimon L., Storey R.F., Vilahur G. Update on lipids, inflammation and atherothrombosis. Thromb Haemost. 2011; 105 (1): 34-42.Badimon L., Storey R.F., Vilahur G. Update on lipids, inflammation and atherothrombosis. Thromb Haemost. 2011; 105 (1): 34-42.Badimon L., Vilahur G. Coronary atherothrombotic disease: progress in antiplatelet therapy. Rev Esp Cardiol. 2008; 61: 501-513.Badimon L., Vilahur G. Coronary atherothrombotic disease: progress in antiplatelet therapy. Rev Esp Cardiol. 2008; 61: 501-513.Battinelli E.M., Bauer K.A. Thrombophilias in pregnancy. Hematol Oncol Clin North Am. 2011 Apr; 25 (2): 323-33.Battinelli E.M., Bauer K.A. Thrombophilias in pregnancy. Hematol Oncol Clin North Am. 2011 Apr; 25 (2): 323-33.Bavbek N., Kargili A., Kaftan О. et al. Elevated concentrations of soluble adhesion molecules and large platelets in diabetic patients: are they markers of vascular disease and diabetic nephropathy? Clin Appl Thromb Hemost. 2007; 13: 391-397.Bavbek N., Kargili A., Kaftan О. et al. Elevated concentrations of soluble adhesion molecules and large platelets in diabetic patients: are they markers of vascular disease and diabetic nephropathy? Clin Appl Thromb Hemost. 2007; 13: 391-397.Boden G. Obesity and free fatty acids. Endocrinol Metab Clin North Am. 2008; 37: 635-646.Boden G. Obesity and free fatty acids. Endocrinol Metab Clin North Am. 2008; 37: 635-646.Corsonello A., Perticone F., Malara A. et al. Leptin- dependent platelet aggregation in healthy, overweight and obese subjects. Int J Obes Relat Metab Disord. 2003; 27: 566-573.Corsonello A., Perticone F., Malara A. et al. Leptin- dependent platelet aggregation in healthy, overweight and obese subjects. Int J Obes Relat Metab Disord. 2003; 27: 566-573.Davi G., Guagnano M.T., Ciabattoni G. et al. Platelet activation in obese women: role of inflammation' and oxidant stress. JAMA. 2002; 288: 2008-2014.Davi G., Guagnano M.T., Ciabattoni G. et al. Platelet activation in obese women: role of inflammation' and oxidant stress. JAMA. 2002; 288: 2008-2014.De Ferranti S., Mozaffarian D. The perfect storm: obesity, adipocyte dysfunction, and metabolic consequences. Clin Chem. 2008; 54: 945-955.De Ferranti S., Mozaffarian D. The perfect storm: obesity, adipocyte dysfunction, and metabolic consequences. Clin Chem. 2008; 54: 945-955.De Pergola G., Pannacciulli N., Coviello M. et al. sP- selectin plasma levels in obesity: association with insulin resistance and related metabolic and pro- thrombotic factors. Nutr Metab Cardiovasc Dis. 2008; 18: 227-232.De Pergola G., Pannacciulli N., Coviello M. et al. sP- selectin plasma levels in obesity: association with insulin resistance and related metabolic and pro- thrombotic factors. Nutr Metab Cardiovasc Dis. 2008; 18: 227-232.Eichinger S., Hron G., Bialonczyk С. et al. Overweight, obesity, and the risk of recurrent venous thromboembolism. Arch Intern Med. 2008; 168: 1678-1683.Eichinger S., Hron G., Bialonczyk С. et al. Overweight, obesity, and the risk of recurrent venous thromboembolism. Arch Intern Med. 2008; 168: 1678-1683.Faber D.R., de Groot P.G., Visseren F.L. Role of adpose tissue in haemostasis, coagulation and fibrnolysis. Obes Rev. 2009; 10: 554-563.Faber D.R., de Groot P.G., Visseren F.L. Role of adpose tissue in haemostasis, coagulation and fibrnolysis. Obes Rev. 2009; 10: 554-563.Furie B., Furie B.C. Mechanisms of thrombus formation. N Engl J Med. 2008; 359: 938-949.Furie B., Furie B.C. Mechanisms of thrombus formation. N Engl J Med. 2008; 359: 938-949.Gaspsyryan A.Y., Ayvazyan L., Mikhailidis D.P., Kitas G.D. Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des. 2011; 17: 47-58.Gaspsyryan A.Y., Ayvazyan L., Mikhailidis D.P., Kitas G.D. Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des. 2011; 17: 47-58.Goralski K.B., Sinai C.J. Type 2 diabetes and cardiovascular disease: getting to the fat of the matter. Can J Physiol Pharmacol. 2007; 85: 113-132.Goralski K.B., Sinai C.J. Type 2 diabetes and cardiovascular disease: getting to the fat of the matter. Can J Physiol Pharmacol. 2007; 85: 113-132.Gregor M.F., Hotamisligil G.S. Thematic review series: Adipocyte Biology. Adipocyte stress: the en doplasmic; reticulum and metabolic disease. J .Lipid Res. 2007; 48: 1905-1914.Gregor M.F., Hotamisligil G.S. Thematic review series: Adipocyte Biology. Adipocyte stress: the en doplasmic; reticulum and metabolic disease. J .Lipid Res. 2007; 48: 1905-1914.Hajer G.R., van Haeften T.W., Visseren F.L. Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. Eur Heart J. 2008; 29: 2959-2971.Hajer G.R., van Haeften T.W., Visseren F.L. Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. Eur Heart J. 2008; 29: 2959-2971.Hernandez Vera R., Vilahur G., Badimon L. Obe sity with insulin resistance increase thrombosis in wild-type and bone marrow-transplanted Zucker fatty rats. Thromb Haemost. 2013; 109: 319-327.Hernandez Vera R., Vilahur G., Badimon L. Obe sity with insulin resistance increase thrombosis in wild-type and bone marrow-transplanted Zucker fatty rats. Thromb Haemost. 2013; 109: 319-327.Hernandez Vera R., Vilahur G., Ferrer-Lorente R. et al. Platelets derived from the bone marrow of diabetic animals show deregulated endoplasmic reticulum stress proteins that contribute to increased thrombosis. Arterioscler Thromb Vase Biol. 2012; 32: 2141-2148.Hernandez Vera R., Vilahur G., Ferrer-Lorente R. et al. Platelets derived from the bone marrow of diabetic animals show deregulated endoplasmic reticulum stress proteins that contribute to increased thrombosis. Arterioscler Thromb Vase Biol. 2012; 32: 2141-2148.Ibanez B., Vilahur G., Badimon J.J. Plaque progression and regression in atherothrombosis. J Thromb Haemost. 2007; 5 (1): 292-299.Ibanez B., Vilahur G., Badimon J.J. Plaque progression and regression in atherothrombosis. J Thromb Haemost. 2007; 5 (1): 292-299.James A.H. Venous thromboembolism in pregnancy. Arterioscler Thromb Vasc Biol. 2009; 29: 326-331.James A.H. Venous thromboembolism in pregnancy. Arterioscler Thromb Vasc Biol. 2009; 29: 326-331.Kato H., Kashiwagi H., Shiraga M. et al. Adiponectin acts as an endogenous antithrombotic factor. Arterioscler Thromb Vase Biol. 2006; 26: 224-230.Kato H., Kashiwagi H., Shiraga M. et al. Adiponectin acts as an endogenous antithrombotic factor. Arterioscler Thromb Vase Biol. 2006; 26: 224-230.Kopp C.W., Kopp H.P., Steiner S. et al. Weight loss reduces tissue factor in morbidly obese patients. Obes Res. 2003; 11: 950-956.Kopp C.W., Kopp H.P., Steiner S. et al. Weight loss reduces tissue factor in morbidly obese patients. Obes Res. 2003; 11: 950-956.Libby P., Ridker P.M., Hansson G.K. Progress and challenges in translating the biology of atherosclerosis. Nature. 2011; 473: 317-325.Libby P., Ridker P.M., Hansson G.K. Progress and challenges in translating the biology of atherosclerosis. Nature. 2011; 473: 317-325.Lijnen H., Collen D. Molecular and cellular basis of fibrinolysis. In: Hoffman R. Benz E.J., Shattil S.J., Furie В. et al. (eds). Elsevier: Philadelphia. 2005.Lijnen H., Collen D. Molecular and cellular basis of fibrinolysis. In: Hoffman R. Benz E.J., Shattil S.J., Furie В. et al. (eds). Elsevier: Philadelphia. 2005.Lumeng C.N., Bodzin J.L., Saltiel A.R. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest. 2007; 117: 175-184.Lumeng C.N., Bodzin J.L., Saltiel A.R. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest. 2007; 117: 175-184.Mattu H.S., Randeva H.S. The role of adipokines in cardiovascular disease. J Endocrinol. 2013; 216: 17-3.Mattu H.S., Randeva H.S. The role of adipokines in cardiovascular disease. J Endocrinol. 2013; 216: 17-3.Maury E., Brichard S.M. Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome. Mol Cell Endocrinol. 2010; 314:1-16.Maury E., Brichard S.M. Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome. Mol Cell Endocrinol. 2010; 314:1-16.Meade T.W., Ruddock V., Stirling Y. et al. Fibrinolytic activity, clotting factors, and long-term incidence of ischaemic heart disease in the Northwick Park Heart Study. Lancet. 1993; 342: 1076-1079.Meade T.W., Ruddock V., Stirling Y. et al. Fibrinolytic activity, clotting factors, and long-term incidence of ischaemic heart disease in the Northwick Park Heart Study. Lancet. 1993; 342: 1076-1079.Molins В., Pena E., de la Torre R., Badimon L. Monomeric C-reactive protein is prothrombotic and dissociates from circulating pentameric C-reactive protein on adhered activated platelets under flow. Cardiovasc Res. 2011; 92: 328-337.Molins В., Pena E., de la Torre R., Badimon L. Monomeric C-reactive protein is prothrombotic and dissociates from circulating pentameric C-reactive protein on adhered activated platelets under flow. Cardiovasc Res. 2011; 92: 328-337.Mottillo S., Filion K.B., Genest J. et al. The metabolic syndrome and cardiovascular risk a systematic review and meta-analysis. Am Coll Cardiol. 2010; 56: 1113-1132.Mottillo S., Filion K.B., Genest J. et al. The metabolic syndrome and cardiovascular risk a systematic review and meta-analysis. Am Coll Cardiol. 2010; 56: 1113-1132.Murakami T., Horigome H., Tanaka K. et al. Impact of weight reduction on production of platelet-derived microparticles and fibrinolytic parameters in obesity. Thromb Res. 2007; 119: 45-53.Murakami T., Horigome H., Tanaka K. et al. Impact of weight reduction on production of platelet-derived microparticles and fibrinolytic parameters in obesity. Thromb Res. 2007; 119: 45-53.Nagai N., Hoylaerts M.F., Cleuren A.C. et al. Obesity promotes injury induced femoral artery thrombosis in mice. Thromb Res. 2008; 122: 549-555.Nagai N., Hoylaerts M.F., Cleuren A.C. et al. Obesity promotes injury induced femoral artery thrombosis in mice. Thromb Res. 2008; 122: 549-555.Napoleone E., Ai D.I., Amore С et al. Leptin induces tissue factor expression in human peripheral blood mononuclear cells: a possibledink between obesity and cardiovascular risk? J Thromb Haemost. 2007; 5: 1462-1468.Napoleone E., Ai D.I., Amore С et al. Leptin induces tissue factor expression in human peripheral blood mononuclear cells: a possibledink between obesity and cardiovascular risk? J Thromb Haemost. 2007; 5: 1462-1468.Natal C., Restituto P., Inigo С. et al. The proinflam- matory mediator CD40 ligand is increased in the metabolic syndrome and modulated by adiponec- tin. J Clin Endocrinol Metab. 2008; 93: 2319-2327.Natal C., Restituto P., Inigo С. et al. The proinflam- matory mediator CD40 ligand is increased in the metabolic syndrome and modulated by adiponec- tin. J Clin Endocrinol Metab. 2008; 93: 2319-2327.Poirier P., Giles T.D., Bray G.A. et al. Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss. Circulation. 2006; 113: 898-918.Poirier P., Giles T.D., Bray G.A. et al. Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss. Circulation. 2006; 113: 898-918.Rega G., Kaun C., Weiss T.W. et al. Inflammatory cytokines interleukin-6 and oncostatin m induce plasminogen activator inhibitor-1 in human adipose tissue. Circulation. 2005; 111: 1938-1945.Rega G., Kaun C., Weiss T.W. et al. Inflammatory cytokines interleukin-6 and oncostatin m induce plasminogen activator inhibitor-1 in human adipose tissue. Circulation. 2005; 111: 1938-1945.Rega-Kaun G., Kaun C., Wojta J. More than a simple storage organ: Adipose tissue as a source of adipokines involved in cardiovascular disease. Thromb Haemost. 2013; 110. DOI:10.1160/TH13-03-0212.Rega-Kaun G., Kaun C., Wojta J. More than a simple storage organ: Adipose tissue as a source of adipokines involved in cardiovascular disease. Thromb Haemost. 2013; 110. DOI:10.1160/TH13-03-0212.Russo I., Traversa M., Bonomo K. et al. In central obesity, weight loss restores platelet sensitivity to nitric oxide and prostacyclin. Obesity. 2010; 18:788-797.Russo I., Traversa M., Bonomo K. et al. In central obesity, weight loss restores platelet sensitivity to nitric oxide and prostacyclin. Obesity. 2010; 18:788-797.Samad F., Pandey M., de Waard V., Loskutoff D. Elevated PAI-1 and tissue factor gene expression in obese mice: a possible mechanism for the increased risk for cardiovascular disease associated with obesity. Fibrinol Proteol. 1997; 11: 17.Samad F., Pandey M., de Waard V., Loskutoff D. Elevated PAI-1 and tissue factor gene expression in obese mice: a possible mechanism for the increased risk for cardiovascular disease associated with obesity. Fibrinol Proteol. 1997; 11: 17.Steffen L.M., Cushman M., Peacock J.M. et al. Metabolic syndrome and risk of venous thromboembolism: Longitudinal Investigation of Thromboembolism Etiology. J Thromb Haemost. 2009; 7: 746-751.Steffen L.M., Cushman M., Peacock J.M. et al. Metabolic syndrome and risk of venous thromboembolism: Longitudinal Investigation of Thromboembolism Etiology. J Thromb Haemost. 2009; 7: 746-751.Targher G., Zoppini G., Moghetti P., Day C.P. Disorders of coagulation and hemostasis in abdominal obesity: emerging role of fatty liver. Semin Thromb Hemost. 2010; 36: 41-48.Targher G., Zoppini G., Moghetti P., Day C.P. Disorders of coagulation and hemostasis in abdominal obesity: emerging role of fatty liver. Semin Thromb Hemost. 2010; 36: 41-48.Xie H., Sheng L., Zhou H., Yan J. The role of TLR4 in pathophysiology of antiphospholipid syndrome-associated thrombosis and pregnancy morbidity. Br J Haematol. 2013 Oct 8. DOI: 10.1111/bjh.12587. [Epub ahead of print].Xie H., Sheng L., Zhou H., Yan J. The role of TLR4 in pathophysiology of antiphospholipid syndrome-associated thrombosis and pregnancy morbidity. Br J Haematol. 2013 Oct 8. DOI: 10.1111/bjh.12587. [Epub ahead of print].
The authors declare that there are no conflicts of interest present.