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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">akusherstvo</journal-id><journal-title-group><journal-title xml:lang="en">Obstetrics, Gynecology and Reproduction</journal-title><trans-title-group xml:lang="ru"><trans-title>Акушерство, Гинекология и Репродукция</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2313-7347</issn><issn pub-type="epub">2500-3194</issn><publisher><publisher-name>IRBIS LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17749/2070-4968.2015.9.3.011-016</article-id><article-id custom-type="elpub" pub-id-type="custom">akusherstvo-166</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ОRIGINAL ARTICLES</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group></article-categories><title-group><article-title>CLINICAL LABORATORY INDICATORS OF PREGNANT WITH ANTIPHOSPHOLIPID SYNDROME IN COMPLEX THERAPY WITH USING INTRAVENOUS IMMUNOGLOBULIN</article-title><trans-title-group xml:lang="ru"><trans-title>КЛИНИКО-ЛАБОРАТОРНЫЕ ПОКАЗАТЕЛИ БЕРЕМЕННЫХ С АНТИФОСФОЛИПИДНЫМ СИНДРОМОМ ПРИ КОМПЛЕКСНОЙ ТЕРАПИИ С ПРИМЕНЕНИЕМ ВНУТРИВЕННОГО ИММУНОГЛОБУЛИНА</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Линников</surname><given-names>В. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Linnikov</surname><given-names>V. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор, научный консультант медико-генетического центра «ГерMедTех»</p></bio><bio xml:lang="en"><p>MD, professor, Senior scientific consultant, Medical Genetic Center «GerMedTech»</p></bio><email xlink:type="simple">germedtech@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Городской центр планирования семьи и репродукции, Одесса, Украина,&#13;
Медико-генетический центр «ГерМедТех», Одесса, Украина</institution><country>Россия</country></aff><aff xml:lang="en"><institution>City Center for Family Planning and Reproduction, Odessa, Ukraine, Medical Genetics Center "GerMedTeh", Odessa, Ukraine</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>19</day><month>06</month><year>2016</year></pub-date><volume>9</volume><issue>3</issue><fpage>11</fpage><lpage>16</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Linnikov V.I., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Линников В.И.</copyright-holder><copyright-holder xml:lang="en">Linnikov V.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.gynecology.su/jour/article/view/166">https://www.gynecology.su/jour/article/view/166</self-uri><abstract/><trans-abstract xml:lang="ru"/><kwd-group xml:lang="ru"><kwd>Антифосфолипидный синдром</kwd><kwd>система гемостаза</kwd><kwd>синдром потери плода</kwd><kwd>внутривенный иммуноглобулин</kwd><kwd>иммунокомпетентные лимфоциты</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Antiphospholipid syndrome</kwd><kwd>hemostasis system</kwd><kwd>fetal loss syndrome</kwd><kwd>inravenous immunoglobulin</kwd><kwd>immunocompetent lymphocytes</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Макацария А.Д., Бицадзе В.О., Хизроева Д.Х., Макацария Н.А., Яшенина Е.В. Патогенетичес- кое значение антифосфолипидных антител. Практическая медицина. 2012; 5: 9-20.</mixed-citation><mixed-citation xml:lang="en">Makatsariya A.D., Bitsadze V.O., Khizroeva D.Kh., Makatsariya N.A., Yashenina E.V. Prakticheskaya meditsina. 2012; 5: 9-20.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Макацария А.Д., Бицадзе В.О. Тромбофилия и противотромботическая терапия в акушерской практике. M. 2003; 904 с.</mixed-citation><mixed-citation xml:lang="en">Makatsariya A.D., Bitsadze V.O. Thrombophilia and antithrombotic therapy in obstetric practice [Trombofiliya i protivotromboticheskaya terapiya v akusherskoi praktike (in Russian)]. Moscow. 2003; 904 s.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Макацария А.Д., Бицадзе В.О., Баймуратова С.М., Долгушина Н.В., Юдаева Л.С., Хизро- ева Д.Х., Акиньшина С.В. Антифосфолипид- ный синдром – иммунная тромбофилия в акушерстве и гинекологии. М. 2013; 485 с.</mixed-citation><mixed-citation xml:lang="en">Makatsariya A.D., Bitsadze V.O., Baimuratova S.M., Dolgushina N.V., Yudaeva L.S., Khizroeva D.Kh., Akin'shina S.V. Antiphospholipid syndrome – the immune thrombophilia in obstetrics and gynecology [Antifosfolipidnyi sindrom – immunnaya trombofiliya v akusherstve i ginekologii (in Russian)]. Moscow. 2013; 485 s.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Сельков А.В., Селютин А.В. Методы опреде- ления содержания Т-регуляторных клеток в периферической крови. Лабораторная диагностика. 2008; 4: 19-21.</mixed-citation><mixed-citation xml:lang="en">Sel'kov A.V., Selyutin A.V. Laboratornaya diagnostika. 2008; 4: 19-21.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Сидельникова В.М. Привычная потеря бере- менности. М. 2005; 304-307.</mixed-citation><mixed-citation xml:lang="en">Sidel'nikova V.M. The usual pregnancy loss [Privychnaya poterya beremennosti (in Russian)]. Moscow. 2005; 304-307.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Ярилин А.А., Донецкова Ф.Д. Регуляторные Т-клетки, зависимые от фактора FOXp3, и перспективы их изучения при беремен- ности. Rus J. Immunol. 2005; 9: 149-152.</mixed-citation><mixed-citation xml:lang="en">Yarilin A.A., Donetskova F.D. Regulyatornye T-kletki, zavisimye ot faktora FOXp3, i perspektivy ikh izucheniya pri beremennosti. Rus J. Immunol. 2005; 9: 149-152.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Branch D.W., Peaceman A.M., Silver R.K. A multicenter, placebo-controlled pilot study of intravenous immune globulin treatment of antiphospholipid syndrome during pregnancy. The Pregnancy Loss Study Group. Am J Obstet Gynecol. 2000; 182 (1): 122-127.</mixed-citation><mixed-citation xml:lang="en">Branch D.W., Peaceman A.M., Silver R.K. A multicenter, placebo-controlled pilot study of intravenous immune globulin treatment of antiphospholipid syndrome during pregnancy. The Pregnancy Loss Study Group. Am J Obstet Gynecol. 2000; 182 (1): 122-127.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Carp H., Sapir T., Shoenfeld Y. Inravenous immunoglobulin and recurrent pregnancy loss. Clin. Rev. Allegy Immunol. 2005; 29 (3): 327-332.</mixed-citation><mixed-citation xml:lang="en">Carp H., Sapir T., Shoenfeld Y. Inravenous immunoglobulin and recurrent pregnancy loss. Clin. Rev. Allegy Immunol. 2005; 29 (3): 327-332.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Coulam C.D., Roussev R.G. Correlation of NK cell activation and inhibition markers with NK cytoxicity among women experiencing immunologic implantation failure after in vitro ferilization and embryotransfer. J. Ass. Reprod. Genet. 2003; 20: 58-62.</mixed-citation><mixed-citation xml:lang="en">Coulam C.D., Roussev R.G. Correlation of NK cell activation and inhibition markers with NK cytoxicity among women experiencing immunologic implantation failure after in vitro ferilization and embryotransfer. J. Ass. Reprod. Genet. 2003; 20: 58-62.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Guerin L.R. Regulatory T-cells and immune tolerance in pregnancy: a new target for infertility treatment? Human Reproduction Update. 2009; 15 (5): 535-571.</mixed-citation><mixed-citation xml:lang="en">Guerin L.R. Regulatory T-cells and immune tolerance in pregnancy: a new target for infertility treatment? Human Reproduction Update. 2009; 15 (5): 535-571.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Chen M.L., Pittet M.J., Gorelik Regulatry I. T-cells suppress tumor-specific CD8 T-cell cytotoxity through TGF-b signals in vivo. Proc. Nath. Acaci. Sci USA. 2005; 102: 409-424.</mixed-citation><mixed-citation xml:lang="en">Chen M.L., Pittet M.J., Gorelik Regulatry I. T-cells suppress tumor-specific CD8 T-cell cytotoxity through TGF-b signals in vivo. Proc. Nath. Acaci. Sci USA. 2005; 102: 409-424.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Christiansen O.D. A randomized, double-blind, placebo-controlled trial of intravenous immunoglobulin in the prevention of recurrent miscarnage evidence for a therapeutic effect in women with secondry recurrent miscamage. Hum. Reprod. 2002; 17: 809-816.</mixed-citation><mixed-citation xml:lang="en">Christiansen O.D. A randomized, double-blind, placebo-controlled trial of intravenous immunoglobulin in the prevention of recurrent miscarnage evidence for a therapeutic effect in women with secondry recurrent miscamage. Hum. Reprod. 2002; 17: 809-816.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Shoenfeld Y., Kutz U. IVIG therapy in autoimmunity and related disorders our experience with a large cohort of patients. Autoimmunity. 2005; 38 (2): 123-137.</mixed-citation><mixed-citation xml:lang="en">Shoenfeld Y., Kutz U. IVIG therapy in autoimmunity and related disorders our experience with a large cohort of patients. Autoimmunity. 2005; 38 (2): 123-137.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Stricker R.B., Stenleitner A., Winger E.E. Intravenous immunoglobulin therapy for immunologic abortion. Clin. Appl. Rev. 2002; 43: 187-199.</mixed-citation><mixed-citation xml:lang="en">Stricker R.B., Stenleitner A., Winger E.E. Intravenous immunoglobulin therapy for immunologic abortion. Clin. Appl. Rev. 2002; 43: 187-199.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Stephenson M. Inravenous immunoglobulin and idiopathic secondary recurrent miscarriage: a multicentered randomized placebocontrolled trial. M. Stephenson. Hum. Reprod. 2010; 25 (9): 2203-1209.</mixed-citation><mixed-citation xml:lang="en">Stephenson M. Inravenous immunoglobulin and idiopathic secondary recurrent miscarriage: a multicentered randomized placebocontrolled trial. M. Stephenson. Hum. Reprod. 2010; 25 (9): 2203-1209.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Tzronkowski P., Szit E., Mysliwska E. CD4+ CD25+ T-regulatory cells ingibit human cytotoxic activity of CTL and NK-cells in humans – impact of immunosensence. Clin. Immunol. 2006; 119: 307-312.</mixed-citation><mixed-citation xml:lang="en">Tzronkowski P., Szit E., Mysliwska E. CD4+ CD25+ T-regulatory cells ingibit human cytotoxic activity of CTL and NK-cells in humans – impact of immunosensence. Clin. Immunol. 2006; 119: 307-312.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Triolo G. IVIG in pregnancy. Lupus. 2004; 13 (9): 731-736.</mixed-citation><mixed-citation xml:lang="en">Triolo G. IVIG in pregnancy. Lupus. 2004; 13 (9): 731-736.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
