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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">akusherstvo</journal-id><journal-title-group><journal-title xml:lang="en">Obstetrics, Gynecology and Reproduction</journal-title><trans-title-group xml:lang="ru"><trans-title>Акушерство, Гинекология и Репродукция</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2313-7347</issn><issn pub-type="epub">2500-3194</issn><publisher><publisher-name>IRBIS LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17749/2313-7347/ob.gyn.rep.2022.343</article-id><article-id custom-type="elpub" pub-id-type="custom">akusherstvo-1468</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL CASES</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ СЛУЧАИ</subject></subj-group></article-categories><title-group><article-title>Analyzing a clinical case of married couple with combined infertility</article-title><trans-title-group xml:lang="ru"><trans-title>Разбор клинического случая семейной пары с комбинированным бесплодием</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ледина</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Ledina</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ледина Антонина Виталиевна – д.м.н., доцент кафедры акушерства, гинекологии и репродуктивной медицины факультета непрерывного медицинского образования Медицинского института ФГАОУ ВО «Российский университет дружбы народов»; врач акушер-гинеколог Клинического госпиталя Лапино, ГК «Мать и Дитя»; вице-президент Общероссийской общественной организации «Российская Ассоциация по генитальным инфекциям и неоплазии»</p><p>117198 Москва, ул. Миклухо-Маклая, д. 6143081 Московская область, Одинцовский район, Лапино, 1-ое Успенское шоссе, д. 111</p></bio><bio xml:lang="en"><p>Antonina V. Ledina – MD, Dr Sci Med, Associate Professor, Department of Obstetrics, Gynecology and Reproductive Medicine, Faculty of Continuing Medical Education, Medical Institute, People's Friendship University of Russia; Obstetrician-Gynecologist, Lapino Clinic Hospital, MD Medical Group; Vice President, All-Russian Public Organization "Russian Association for Genital Infections and Neoplasia"</p><p>117198, Moscow, Miklukho-Maklaya Str., 6143081, Moscow Region, Odintsovo District, Lapino, 1st Uspenskoye Highway, 111</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4678-6841</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кетова</surname><given-names>Г. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Ketova</surname><given-names>G. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кетова Галина Григорьевна – д.м.н., профессор кафедры поликлинической терапии и клинической фармакологии, зав. отделением Клиники Южно-Уральский государственный медицинский университет» Министерства здравоохранения Российской Федерации; главный внештатный клинический фармаколог Челябинской области</p><p>454048 Челябинск, ул. Воровского, д. 64</p></bio><bio xml:lang="en"><p>Galina G. Ketova – МD, Dr Med Sci, Professor, Head of the Department of Polyclinic Therapy and Clinical Pharmacology, Clinic of the South Ural State Medical University; Chief Freelance Clinical Pharmacologist of the Chelyabinsk Region</p><p>454092, Chelyabinsk, Vorovskogo Str., 64</p></bio><email xlink:type="simple">galina_ketova@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО « Российский университет дружбы народов»; Клинический госпиталь Лапино, ГК «Мать и Дитя»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>People's Friendship University of Russia; Lapino Clinic Hospital, MD Medical Group</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО «Южно-Уральский государственный медицинский университет» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>South Ural State Medical University, Health Ministry of Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>04</day><month>11</month><year>2022</year></pub-date><volume>16</volume><issue>5</issue><fpage>623</fpage><lpage>630</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ledina A.V., Ketova G.G., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Ледина А.В., Кетова Г.Г.</copyright-holder><copyright-holder xml:lang="en">Ledina A.V., Ketova G.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.gynecology.su/jour/article/view/1468">https://www.gynecology.su/jour/article/view/1468</self-uri><abstract><p>Infertility is a disease of the reproductive system characterized by lacked clinical pregnancy after 12 or more months of regular unprotected sex. To diagnose the causes and choose the tactics of infertility treatment, a personalized approach to each patient is required, which is beneficial for both the doctor and the patient. A comprehensive examination of patients is important from the point of pharmacoeconomics and clinical efficiency view. Here, a comprehensive diagnostics of the spouses resulting in birth of a healthy child is discussed.</p></abstract><trans-abstract xml:lang="ru"><p>Бесплодие – это заболевание репродуктивной системы, характеризующееся отсутствием наступления клинической беременности после 12 и более месяцев регулярных незащищенных половых контактов. Для диагностики причин и выбора тактики лечения бесплодия необходим персонифицированный подход к каждому пациенту, который выгоден как для врача, так и для пациента. Комплексное обследование пациентов важно с точки зрения фармакоэкономики и эффективности. В данной статье рассмотрена комплексная диагностика супругов, в результате у пары родился здоровый ребенок.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>урология</kwd><kwd>гинекология</kwd><kwd>бесплодие мужское</kwd><kwd>бесплодие женское</kwd><kwd>комбинированное бесплодие</kwd><kwd>лабораторная диагностика</kwd><kwd>генетические нарушения</kwd><kwd>кариотипирование</kwd><kwd>Гемотест</kwd><kwd>обязательное медицинское страхование</kwd><kwd>ОМС</kwd></kwd-group><kwd-group xml:lang="en"><kwd>urology</kwd><kwd>gynecology</kwd><kwd>male infertility</kwd><kwd>female infertility</kwd><kwd>combined infertility</kwd><kwd>laboratory diagnostics</kwd><kwd>genetic disorders</kwd><kwd>karyotyping</kwd><kwd>Gemotest</kwd><kwd>compulsory health insurance</kwd><kwd>CHI</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Бесплодие. Всемирная организация здравоохранения, 2020. Режим доступа: https://www.who.int/ru/news-room/fact-sheets/detail/infertility. [Дата обращения: 20.07.2022].</mixed-citation><mixed-citation xml:lang="en">Infertility. [Besplodie]. Vsemirnaya organizaciya zdravoohraneniya, 2020. (In Russ.). Available at: https://www.who.int/ru/news-room/fact-sheets/detail/infertility. [Accessed: 20.07.2022].</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Szamatowicz M., Szamatowicz J. Proven and unproven methods for diagnosis and treatment of infertility. Adv Med Sci. 2020;65(1):93–6. https://doi.org/10.1016/j.advms.2019.12.008.</mixed-citation><mixed-citation xml:lang="en">Szamatowicz M., Szamatowicz J. Proven and unproven methods for diagnosis and treatment of infertility. Adv Med Sci. 2020;65(1):93–6. https://doi.org/10.1016/j.advms.2019.12.008.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Клинические рекомендации. Мужское бесплодие. М.: Министерство здравоохранения Российской Федерации, 2021. 25 с. Режим доступа: http://disuria.ru/_ld/10/1013_kr21N46mz.pdf. [Дата обращения: 20.07.2022].</mixed-citation><mixed-citation xml:lang="en">Clinical guidelines. Male infertility. [Klinicheskie rekomendacii. Muzhskoe besplodie]. Moscow: Ministerstvo zdravoohraneniya Rossijskoj Federacii, 2021. 25 p. (In Russ.). Available at: http://disuria.ru/_ld/10/1013_kr21N46mz.pdf. [Accessed: 20.07.2022].</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Improving Diagnosis in Health Care. Committee on Diagnostic Error in Health Care; Board on Health Care Services; Institute of Medicine; The National Academies of Sciences, Engineering, and Medicine. Eds. E.P. Balogh, B.T. Miller, J.R. Ball. Washington (DC): National Academies Press (US), 2015. 472 p. https://doi.org/10.17226/21794.</mixed-citation><mixed-citation xml:lang="en">Improving Diagnosis in Health Care. Committee on Diagnostic Error in Health Care; Board on Health Care Services; Institute of Medicine; The National Academies of Sciences, Engineering, and Medicine. Eds. E.P. Balogh, B.T. Miller, J.R. Ball. Washington (DC): National Academies Press (US), 2015. 472 p. https://doi.org/10.17226/21794.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Infertility Workup for the Women’s Health Specialist. Committee on Gynecologic Practice. American Society for Reproductive Medicine. Number 781 (Reaffirmed 2020). Available at: https://www.acog.org/clinical/clinical-guidance/committee-opinion/articles/2019/06/infertilityworkup-for-the-womens-health-specialist. [Accessed: 20.07.2022].</mixed-citation><mixed-citation xml:lang="en">Infertility Workup for the Women’s Health Specialist. Committee on Gynecologic Practice. American Society for Reproductive Medicine. Number 781 (Reaffirmed 2020). Available at: https://www.acog.org/clinical/clinical-guidance/committee-opinion/articles/2019/06/infertilityworkup-for-the-womens-health-specialist. [Accessed: 20.07.2022].</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Клинические рекомендации. Женское бесплодие. М.: Министерство здравоохранения Российской Федерации, 2021. 50 с. Режим доступа: https://moniiag.ru/wp-content/uploads/2019/07/Klinicheskierekomendatsii.-ZHenskoe-besplodie.pdf. [Дата обращения: 20.07.2022].</mixed-citation><mixed-citation xml:lang="en">Clinical guidelines. Female infertility. [Klinicheskie rekomendacii. Zhenskoe besplodie]. Moscow: Ministerstvo zdravoohraneniya Rossijskoj Federacii, 2021. 50 p. (In Russ.). Available at: https://moniiag.ru/wp-content/uploads/2019/07/Klinicheskie-rekomendatsii.-ZHenskoebesplodie.pdf. [Accessed: 20.07.2022].</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Клинические рекомендации. Эректильная дисфункция. М.: Министерство здравоохранения Российской Федерации, 2021. 20 с. Режим доступа: http://disuria.ru/_ld/11/1133_kr21F52N48p4MZ.pdf. [Дата обращения: 20.07.2022].</mixed-citation><mixed-citation xml:lang="en">Clinical guidelines. Erectile dysfunction. [Klinicheskie rekomendacii. Erektil'naya disfunkciya]. Moscow: Ministerstvo zdravoohraneniya Rossijskoj Federacii, 2021. 20 p. (In Russ.). Available at: http://disuria.ru/_ld/11/1133_kr21F52N48p4MZ.pdf. [Accessed: 20.07.2022].</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
