akusherstvoObstetrics, Gynecology and ReproductionАкушерство, Гинекология и Репродукция2313-73472500-3194IRBIS LLC10.17749/2313-7347/ob.gyn.rep.2022.355akusherstvo-1467Research ArticleREVIEW ARTICLESНАУЧНЫЕ ОБЗОРЫThromboinflammation in oncogynecological patientsТромбовоспаление у онкологических больныхhttps://orcid.org/0000-0001-7441-2778СлуханчукЕ. В.SlukhanchukE. V.

Слуханчук Екатерина Викторовна – к.м.н., доцент кафедры акушерства и гинекологии Клинического института детского здоровья имени Н.Ф. Филатова

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Ekaterina V. Slukhanchuk – MD, PhD, Associate Professor, Department of Obstetrics and Gynecology, Filatov Clinical Institute of Children’s Health

119991, Moscow, Bolshaya Pirogovskaya Str., 2 bldg. 4

ekaterina@ginekologhirurg.ruhttps://orcid.org/0000-0001-8404-1042БицадзеВ. О.BitsadzeV. O.

Бицадзе Виктория Омаровна – д.м.н., профессор РАН, профессор кафедры акушерства и гинекологии Клинического института детского здоровья имени Н.Ф. ФилатоваScopus Author ID: 6506003478Researcher ID: F-8409-2017

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Victoria O. Bitsadze – MD, Dr Sci Med, Professor of RAS, Professor, Department of Obstetrics and Gynecology, Filatov Clinical Institute of Children’s HealthScopus Author ID: 6506003478Researcher ID: F-8409-2017

119991, Moscow, Bolshaya Pirogovskaya Str., 2 bldg. 4

https://orcid.org/0000-0002-7456-2386СолоповаА. Г.SolopovaA. G.

Солопова Антонина Григорьевна – д.м.н., профессор кафедры акушерства и гинекологии Клинического института детского здоровья имени Н.Ф. ФилатоваScopus Author ID: 6505479504Researcher ID: Q-1385-2015

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Antonina G. Solopova – MD, Dr Sci Med, Professor, Department of Obstetrics and Gynecology, Filatov Clinical Institute of Children's HealthScopus Author ID: 6505479504Researcher ID: Q-1385-2015

119991, Moscow, Bolshaya Pirogovskaya Str., 2 bldg. 4

https://orcid.org/0000-0002-0725-9686ХизроеваД. Х.KhizroevaJ. Kh.

Хизроева Джамиля Хизриевна – д.м.н., профессор кафедры акушерства и гинекологии Клинического института детского здоровья имени Н.Ф. ФилатоваScopus Author ID: 57194547147Researcher ID: F-8384-2017

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Jamilya Kh. Khizroeva – MD, Dr Sci Med, Professor, Department of Obstetrics and Gynecology, Filatov Clinical Institute of Children’s HealthScopus Author ID: 57194547147Researcher ID: F-8384-2017

119991, Moscow, Bolshaya Pirogovskaya Str., 2 bldg. 4

https://orcid.org/0000-0002-9899-9910ГриЖ.-К.GrisJ.-S.

Гри Жан-Кристоф – д.м.н., профессор кафедры акушерства и гинекологии Клинического института детского здоровья имени Н.Ф. Филатова ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет); профессор гематологии, зав. лабораторией гематологии факультета биологических и фармацевтических наук Университета Монпелье и Университетской больницы Нима; иностранный член РАНScopus Author ID: 7005114260Researcher ID: AAA-2923-2019

119991 Москва, ул. Большая Пироговская, д. 2, стр. 434090, Франция, Монпелье, ул. Огюста Бруссоне, д. 163

Jean-Christophe Gris – MD, Dr Sci Med, Professor, Department of Obstetrics and Gynecology, Filatov Clinical Institute of Children’s Health, Sechenov University; Professor of Haematology, Head of the Laboratory of Haematology, Faculty of Biological and Pharmaceutical Sciences, Montpellier University and University Hospital of Nîmes; Foreign Member of RASScopus Author ID: 7005114260Researcher ID: AAA-2923-2019

119991, Moscow, Bolshaya Pirogovskaya Str., 2 bldg. 434090, France, Montpellier, Rue Auguste Broussonnet, 163

https://orcid.org/0000-0002-9576-1368ЭлаламиИ.ElalamyI.

Элалами Исмаил – д.м.н., профессор кафедры акушерства и гинекологии Клинического института детского здоровья имени Н.Ф. Филатова ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет); профессор медицинского Университета Сорбонны; директор гематологии Центра Тромбозов, Госпиталь ТенонScopus Author ID: 7003652413Researcher ID: AAC-9695- 2019

119991 Москва, ул. Большая Пироговская, д. 2, стр. 475006, Франция, Париж, Улица медицинского факультета, д. 1275020, Франция, Париж, Китайская улица, д. 4

Ismail Elalamy – MD, Dr Sci Med, Professor, Department of Obstetrics and Gynecology, Filatov Clinical Institute of Children’s Health, Sechenov University; Professor, Medicine Sorbonne University; Director of Hematology, Department of Thrombosis Center, Hospital TenonScopus Author ID: 7003652413Researcher ID: AAC-9695-2019

119991, Moscow, Bolshaya Pirogovskaya Str., 2 bldg. 475006, France, Paris, Rue de l’École de Médecine, 1275020, France, Paris, Rue de la Chine, 4

https://orcid.org/0000-0002-1339-4155ПанкратьеваЛ. Л.PankratyevaL. L.

Панкратьева Людмила Леонидовна – д.м.н., руководитель научно-клинического центра ГБУЗ «Городская клиническая больница № 67 имени Л.А. Ворохобова Департамента здравоохранения города Москвы»; врач-неонатолог, врач-гематолог, доцент, профессор кафедры педиатрии и организации здравоохранения ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии имени Дмитрия Рогачева» Министерства здравоохранения Российской ФедерацииScopus Author ID: 7006391091Author ID: 697284

123423 Москва, ул. Саляма Адиля, д. 2/44117997 Москва, ул. Саморы Машела, д. 1

Liudmila L. Pankratyeva – MD, Dr Sci Med, Head of the Clinical Research Center, Vorokhobov City Clinical Hospital № 67; Neonatologist, Hematologist, Associate Professor, Professor, Department of Pediatrics and Health Organization, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and ImmunologyScopus Author ID: 7006391091Author ID: 697284

123423, Moscow, Salyama Adilya Str., 2/44117997, Moscow, Samora Machel Str., 1

https://orcid.org/0000-0001-5888-0774ЦибизоваВ. И.TsibizovaV. I.

Цибизова Валентина Ивановна – к.м.н., врач акушер-гинеколог НИЛ оперативной гинекологии Института перинатологии и педиатрии, врач отделения функциональной ультразвуковой диагностики

197341 Санкт-Петербург, ул. Аккуратова, д. 2

Valentina I. Tsibizova – MD, PhD, Obstetrician-Gynecologist, Research Laboratory of Operative Gynecology, Institute of Perinatology and Pediatrics; Physician, Department of Functional and Ultrasound Diagnostics

197341, Saint Petersburg, Akkuratova Str., 2

https://orcid.org/0000-0002-3337-4995УнгиадзеД. Ю.UngiadzeJ. Yu.

Унгиадзе Джумбер Юрьевич – д.м.н., профессор медицинского факультета, Батумский государственный университет имени Шота Руставели; директор Центра здоровья «Медина» имени Ирис Борчашвили

6010 Батуми, ул. Ниношвили, д. 356004 Батуми, проспект Фридон Халваши, д. 237

Jumber Yu. Ungiadze – MD, Dr Sci Med, Professor, Faculty of Medicine, Batumi Shota Rustaveli State University; Director of the Iris Borchashvili Health Center «Medina»

6010, Batumi, Ninoshvili Str., 356004, Batumi, Fridon Khalvashi Avenue, 237

https://orcid.org/0000-0001-6396-4948АшрафянЛ. А.AshrafyanL. A.

Ашрафян Лев Андреевич – д.м.н., профессор, академик РАН, заслуженный врач РФ, директор Института онкогинекологии и маммологии, зам. директораScopus Author ID: 57194173388SPIN-код: 4870-1626

117997 Москва, ул. академика Опарина, д. 4

Levon A. Ashrafyan – MD, Dr Sci Med, Professor, Academician of RAS, Honored Doctor of RF, Head of the Institute of Oncogynecology and Mammology, Deputy Director of Kulakov National Medical Research Center for Obstetrics, Gynecology and PerinatologyScopus Author ID: 57194173388

117997, Moscow, Academika Oparina Str., 4

https://orcid.org/0000-0001-7415-4633МакацарияА. Д.MakatsariyaA. D.

Макацария Александр Давидович – д.м.н., профессор, академик РАН, зав. кафедрой акушерства и гинекологии Клинического института детского здоровья имени Н.Ф. ФилатоваScopus Author ID: 57222220144Researcher ID: M-5660-2016

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Alexander D. Makatsariya – MD, Dr Sci Med, Academician of RAS, Professor, Head of the Department of Obstetrics and Gynecology, Filatov Clinical Institute of Children’s HealthScopus Author ID: 57222220144Researcher ID: M-5660-2016

119991, Moscow, Bolshaya Pirogovskaya Str., 2 bldg. 4

ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет)РоссияSechenov UniversityRussian FederationФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет); Университет МонпельеРоссияSechenov University; University of MontpellierRussian FederationФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет); Медицинский Университет Сорбонны; Госпиталь ТенонРоссияSechenov University; Medicine Sorbonne University; Hospital TenonRussian FederationГБУЗ «Городская клиническая больница № 67 имени Л.А. Ворохобова Департамента здравоохранения города Москвы»; ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии имени Дмитрия Рогачева» Министерства здравоохранения Российской ФедерацииРоссияVorokhobov City Clinical Hospital № 67, Moscow Healthcare Department; Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Health Ministry of Russian FederationRussian FederationФГБУ «Национальный медицинский исследовательский центр имени В.А. Алмазова» Министерства здравоохранения Российской ФедерацииРоссияAlmazov National Medical Research Centre, Health Ministry of Russian FederationRussian FederationБатумский государственный университет имени Шота Руставели; Центр здоровья «Медина» имени Ирис БорчашвилиГрузияShota Rustaveli Batumi State University; Iris Borchashvili Health Center «Medina»GeorgiaФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова» Министерства здравоохранения Российской ФедерацииРоссияKulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Health Ministry of Russian FederationRussian Federation202204112022165611622Copyright © Slukhanchuk E.V., Bitsadze V.O., Solopova A.G., Khizroeva J.K., Gris J., Elalamy I., Pankratyeva L.L., Tsibizova V.I., Ungiadze J.Y., Ashrafyan L.A., Makatsariya A.D., 20222022Слуханчук Е.В., Бицадзе В.О., Солопова А.Г., Хизроева Д.Х., Гри Ж., Элалами И., Панкратьева Л.Л., Цибизова В.И., Унгиадзе Д.Ю., Ашрафян Л.А., Макацария А.Д.Slukhanchuk E.V., Bitsadze V.O., Solopova A.G., Khizroeva J.K., Gris J., Elalamy I., Pankratyeva L.L., Tsibizova V.I., Ungiadze J.Y., Ashrafyan L.A., Makatsariya A.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gynecology.su/jour/article/view/1467

Studies of the pathogenesis of thrombosis and inflammation and their contribution to tumor progression and metastasis in cancer patients, initiated many decades ago, have been continued to this day. At the same time, thrombosis and inflammation are inextricably linked to each other. One of the central places in thromboinflammation is held by the loss of normal antithrombotic and anti-inflammatory function in endothelial cells, which leads to dysregulated coagulation, imbalanced the complement system, platelet activation and recruitment of leukocytes in the microvasculature. In turn, tumor cells affect the hemostasis by releasing procoagulant substances, activating fibrinolysis, proteolysis, increasing platelet activation and aggregation, releasing adhesion molecules, secreting pro-inflammatory and pro-angiogenic cytokines. Future research aims to advance an understanding of thromboinflammation in oncology, particularly focusing on the role of platelets beyond hemostasis and thrombosis, as well as some new players in the process. In the future, the main attention will be paid to investigating molecular mechanisms that regulate cancer-related thromboinflammation, providing insights into mechanisms underlying both inflammation and thrombosis as pathogenetic components in cancer patients. Altogether, it will provide an opportunity to create new, modern strategies to treat cancer patients.

Исследования патогенеза тромбоза и воспаления и их вклад в прогрессию опухоли и метастазирование у онкологических больных, начатые много десятилетий назад, продолжаются и в наши дни. При этом тромбообразование и воспаление неразрывно связаны друг с другом. Одно из центральных мест в тромбовоспалении занимает потеря нормальной антитромботической и противовоспалительной функций клетками эндотелия, что приводит к нарушению регуляции коагуляции, дисбалансу в системе комплемента, активации тромбоцитов и рекрутированию лейкоцитов в микроциркуляторном русле. Опухолевые клетки сами влияют на систему гемостаза путем высвобождения прокоагулянтных субстанций, активации фибринолиза, протеолиза, повышая активацию и агрегацию тромбоцитов, выделяя молекулы адгезии, секретируя провоспалительные и проангиогенные цитокины. Современные исследования направлены на углубление понимания патогенеза тромбовоспаления в онкологии с особым акцентом на роль тромбоцитов, а также ряда новых участников процесса. Основное внимание уделяется изучению молекулярных механизмов, регулирующих тромбовоспаление при раке, обеспечивая понимание механизмов как воспаления, так и тромбоза как составных частей патогенеза у онкологических больных. Все это даст возможность для создания новых, современных стратегий терапии онкологических больных.

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The authors declare that there are no conflicts of interest present.