References

akusherstvo

Obstetrics, Gynecology and Reproduction

Акушерство, Гинекология и Репродукция

2313-73472500-3194

IRBIS LLC

10.17749/2313-7347/ob.gyn.rep.2022.295

akusherstvo-1464

Research Article

REVIEW ARTICLES

НАУЧНЫЕ ОБЗОРЫ

Ovarian carcinosarcoma (a literature review)

Карциносаркома яичников (обзор литературы)

https://orcid.org/0000-0003-4915-2219

Бейшембаев

А. М.

Beishembaev

A. M.

Бейшембаев Алмаз Мукашевич – к.м.н., зав. кафедрой онкологии, гематологии, лучевой диагностики и терапии факультета усовершенствования врачей

720064 Бишкек, ул. Боконбаева, д. 144а

Almaz М. Beishembaev – MD, PhD, Head of the Department of Oncology, Hematology, Radiation Diagnostics and Therapy, Faculty of Advanced Medical Education

720064, Bishkek, Bokonbaev Str., 144а

almazyaka@yandex.ru

https://orcid.org/0000-0001-7931-2338

Жорданиа

К. И.

Zhordania

K. I.

Жорданиа Кирилл Иосифович – д.м.н., профессор, онкогинеколог, ведущий научный сотрудник отделения гинекологии

115478 Москва, Каширское шоссе, д. 24

Kirill I. Zhordania – MD, Dr Sci Med, Gynecologist-Oncologist, Leading Researcher, Department of Gynecology

115478, Moscow, Kashirskoe Highway, 24

https://orcid.org/0000-0003-0404-7749

Чой

Э. Д.

Choi

E. D.

Чой Эн Джун – д.м.н., и.о. доцента кафедры хирургических и специальных клинических дисциплин

720000 Бишкек, ул. Анкара, 1/17

En D. Choi – MD, Dr Sci Med, Acting Associate Professor, Department of Surgical and Special Clinical Disciplines

720000, Bishkek, Ankara Str., 1/17

https://orcid.org/0000-0002-6440-5395

Туркменов

А. А.

Turkmenov

A. A.

Туркменов Алыбек Альбертович – к.м.н., и.о. доцента кафедры пропедевтической хирургии

720020 Бишкек, ул. И.К. Ахунбаева, д. 92

Alybek А. Turkmenov – MD, PhD, Acting Associate Professor, Department of Propaedeutic Surgery

720020, Bishkek, Akhunbaev Str., 92

Молдобекова

А. К.

Moldobekova

A. K.

Молдобекова Айпери Кемелбековна – ассистент кафедры хирургических дисциплин

Кант, ул. Гагарина, д. 58

Aiperi K. Moldobekova – MD, Assistant, Department of Surgical Disciplines

Kant, Gagarin Str., 58

Кыргызский государственный медицинский институт переподготовки и повышения квалификации имени С.Б. Даниярова Министерства здравоохранения Кыргызской РеспубликиКыргызстанDaniyarov Kyrgyz State Medical Institute of Advanced Training and RetrainingKyrgyzstan

ФГБУ «Национальный медицинский исследовательский центр онкологии имени Н.Н. Блохина» Министерства здравоохранения Российской ФедерацииРоссияBlokhin National Medical Research Center of OncologyRussian Federation

Международный медицинский университетКыргызстанInternational Medical UniversityKyrgyzstan

Кыргызская государственная медицинская академия имени И.К. АхунбаеваКыргызстанAkhunbaev Kyrgyz State Medical AcademyKyrgyzstan

Азиатский медицинский институт имени С. ТентишеваКыргызстанTentishev Asian Medical InstituteKyrgyzstan

2022

03112022

165575587

2022

Бейшембаев А.М., Жорданиа К.И., Чой Э.Д., Туркменов А.А., Молдобекова А.К.

Beishembaev A.M., Zhordania K.I., Choi E.D., Turkmenov A.A., Moldobekova A.K.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.gynecology.su/jour/article/view/1464

Introduction. Despite that ovarian carcinosarcoma (OCS) is an extremely rare disease, it is of great medical and social importance by taking into account very high level of overall mortality, recurrence, metastasis, and economic costs.Aim: to summarize current data on various aspects of OCS.Materials and Methods. The search strategy for English written papers published in databases PubMed/MEDLINE, Scopus, Web of Science, Google Scholar was based on the following keyword queries: «ovarian carcinosarcoma», «etiology and pathogenesis», «epidemiology», «classification», «clinical picture», «diagnosis», «treatment». The search depth was limited within the years 2010–2022, by prioritizing the search depth within the last 5 years (2017–2022).Results. We found 48 articles in English, published from 2016 to 2022, of which 47 (97.9 %) articles were published within the last 5 years. Scientific data are represented by studies with a small patient sample and with low evidence base. The results of the analysis for identified publications showed a limited, fragmented and inconsistent scientific data both in terms of etiology, pathogenesis and treatment, as well as an impact of OCS stages, age and other risk factors on the likelihood of relapses.Conclusion. The lack of extensive clinical studies along with observed substantial number of controversial issues may be accounted for by OCS low prevalence and complex pathogenesis. Nevertheless, the results obtained during the generalization of scientific knowledge provide a realistic insight into the current state of global science about this medical and social disease and may be used to improve the diagnostics and treatment of OCS patients.

Введение. Несмотря на то что карциносаркома яичников (КСЯ) встречается крайне редко, данное заболевание имеет огромное медико-социальное значение с учетом очень высокой степени общей смертности, рецидивности, метастазирования, экономических расходов на ведение пациентов.Цель: обобщить современные научные данные о КСЯ.Материалы и методы. Стратегия поиска полнотекстовых статей на английском языке, опубликованных в PubMed/MEDLINE, Scopus, Web of Science, Google Scholar, была основана на следующих ключевых словах: «ovarian carcinosarcoma», «etiology and pathogenesis», «epidemiology», «classification», «clinical picture», «diagnosis», «treatment». Глубина поиска составила 2010–2022 гг., приоритет был сделан на глубину поиска за последние 5 лет (2017–2022 гг.).Результаты. Обнаружены 48 статей на английском языке, опубликованные с 2016 по 2022 гг., из них 47 (97,9 %) статей опубликованы за последние 5 лет. Научное знание представлено исследованиями с малой выборкой пациентов и с невысокой доказательной базой. Результаты анализа выявленных публикаций показали ограниченность, фрагментированность и противоречивость научных данных как в вопросах этиологии, патогенеза и лечения, так и влияния стадий КСЯ, возраста и других факторов риска на вероятность рецидивов.Заключение. Отсутствие обширных клинических исследований и наличие огромного количества спорных моментов можно объяснить малой распространенностью и сложным патогенезом КСЯ. Тем не менее полученные в ходе обобщения научного знания результаты дают реальное представление о современном состоянии мировой науки о данном медико-социальном заболевании и могут быть использованы врачами для улучшения диагностики и лечения пациенток с КСЯ.

карциносаркома яичниковКСЯэтиология и патогенезэпидемиологияклассификацияклиническая картинадиагностикалечение

ovarian carcinosarcomaOCSetiology and pathogenesisepidemiologyclassificationclinical picturediagnosistreatment

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The authors declare that there are no conflicts of interest present.