akusherstvoObstetrics, Gynecology and ReproductionАкушерство, Гинекология и Репродукция2313-73472500-3194IRBIS LLC10.17749/2313-7347.2015.9.1.019-031akusherstvo-142Research ArticleОRIGINAL ARTICLESОРИГИНАЛЬНЫЕ СТАТЬИTHE SIGNIFICANCE OF IMMUNOMODULATORY THERAPY IN PREGRAVIDAL PREPARATION OF THE PATIENTS WITH RECURRENT HSV TYPE 2ЗНАЧЕНИЕ ИММУНОМОДУЛИРУЮЩЕЙ ТЕРАПИИ ПРИ ПРЕГРАВИДАРНОЙ ПОДГОТОВКЕ ПАЦИЕНТОК С РЕЦИДИВИРУЮЩИМ ВПГ 2-ГО ТИПАМинаевН. Н.MinaevN. N.

д.м.н., профессор, заведующий кафедрой акушерства и гинекологии

hD, MD, professor, Head of the Department of Obstetrics and Gynecology

mnn@vmail.ruБугримовД. Ю.BugrimovD. Ju.

к.м.н. советник РАЕ, магистр МАНЭБ, старший научный сотрудник, директор НИИ эксперимен-тальной биологии и медицины

PhD, advisor RAE master MANEB, Senior Researcher, Director of the Institute of Experimental Biology

and

danikst@mail.ruКлимовичА. А.KlimovichA. A.

научный сотрудник НИИ экспериментальной биологии и медицины

researcher of the Institute of Experimental Biology and Medicine

klimovich@gmail.comГБОУ ВПО «Воронежская Государственная Медицинская Академия имени Н.Н. Бурденко» Минздрава РоссииРоссияVoronezh State Medical Academy named after NN Burdenko Russian Ministry of HealthRussian Federation201515062016911931Copyright © Minaev N.N., Bugrimov D.J., Klimovich A.A., 20162016Минаев Н.Н., Бугримов Д.Ю., Климович А.А.Minaev N.N., Bugrimov D.J., Klimovich A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gynecology.su/jour/article/view/142

Herpes simplex virus type 1 (HSV-1) and 2 (HSV-2) - is a widespread viruses that can form a lifelong infection and persistence. Genital herpes in women of childbearing age is a serious risk of vertical transmission from mother to fetus. Primary HSV infection and the first episode of genital HSV infections are particularly high risk of infection of the fetus and newborn. The infection rarely occurs in the uterus. Most often the virus is transmitted during childbirth. The greatest risk of transmission to the fetus and the newborn in the case of primary maternal infection occurred during the second half of pregnancy. The risk of transmission from mother to fetus and newborn, can be reduced or the appointment of antiviral drugs, or in specific cases, caesarean section. The purpose of this paper is to propose a possible strategy to prevent transmission of the virus from an infected mother to the fetus.

Вирус простого герпеса типа 1 (ВПГ-1) и 2 (ВПГ-2) - широко распространенные вирусы, способные формировать пожизненную инфекцию и персистенцию. Генитальный герпес у женщин детородного возраста представляет собой серьезный риск вертикальной передачи инфекции от матери к плоду. Первичные ВПГ-инфекции и первые клинические эпизоды генитальной ВПГ-инфекции представляют особенно высокий риск инфицирования плода и новорожденного. Заражение редко происходит в полости матки, чаще всего вирус передается во время родов. Наибольший риск передачи инфекции плоду и новорожденному имеет место в случае первичной материнской инфекции, наступившей во второй половине беременности. Риск передачи заболевания от матери плоду и новорожденному может быть уменьшен назначением противовирусных препаратов или, в конкретных случаях, выполнением кесарева сечения. Целью данной работы является предложение одной из возможных стратегий профилактики передачи вируса от инфицированной матери плоду.

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The authors declare that there are no conflicts of interest present.