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akusherstvo

Obstetrics, Gynecology and Reproduction

Акушерство, Гинекология и Репродукция

2313-73472500-3194

IRBIS LLC

10.17749/2313-7347/ob.gyn.rep.2022.315

akusherstvo-1361

Research Article

REVIEW ARTICLES

НАУЧНЫЕ ОБЗОРЫ

Preeclampsia and venous thromboembolism

Преэклампсия и вопросы венозной тромбоэмболии

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Victoria O. Bitsadze – MD, Dr Sci Med, Professor of RAS, Professor, Department of Obstetrics and Gynecology, Filatov Clinical Institute of Children’s Health

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Хизроева

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Jamilya Kh. Khizroeva – MD, Dr Sci Med, Professor, Department of Obstetrics and Gynecology, Filatov Clinical Institute of Children’s Health

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Слуханчук

Е. В.

Slukhanchuk

E. V.

Слуханчук Екатерина Викторовна – кандидат медицинских наук, доцент кафедры акушерства и гинекологии Клинического института детского здоровья имени Н.Ф. Филатова ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет); врач акушер-гинеколог отделения абдоминальной хирургии и онкологии 2, ФГБНУ «Российский научный центр хирургии имени академика Б.В. Петровского»

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Ekaterina V. Slukhanchuk – MD, PhD, Associate Professor, Department of Obstetrics and Gynecology, Filatov Clinical Institute of Children’s Health, Sechenov University; Obstetrician-Gynecologist, Department of Abdominal Surgery and Oncology 2, Petrovsky National Research Centre of Surgery

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991,

2 Abrikosovskiy Lane, Moscow 119991

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Третьякова

М. В.

Tretyakova

M. V.

Третьякова Мария Владимировна – кандидат медицинских наук, врач акушер-гинеколог, ассистент кафедры акушерства и гинекологии Клинического института детского здоровья имени Н.Ф. Филатова

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Maria V. Tretyakova – MD, PhD, Obstetrician-Gynecologist, Assistant, Department of Obstetrics and Gynecology, Filatov Clinical Institute of Children’s Health

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

https://orcid.org/0000-0002-2541-3843

Макацария

Н. А.

Makatsariya

N. A.

Макацария Наталия Александровна – кандидат медицинских наук, доцент кафедры акушерства и гинекологии Клинического института детского здоровья имени Н.Ф. Филатова

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Researcher ID: F-8406-2017

Nataliya A. Makatsariya – MD, PhD, Associate Professor, Department of Obstetrics and Gynecology, Filatov Clinical Institute of Children's Health

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

Researcher ID: F-8406-2017

https://orcid.org/0000-0002-9899-9910

Гри

Ж.-К. А.

Gris

J.-Ch.

Гри Жан-Кристоф – доктор медицинских наук, профессор кафедры акушерства и гинекологии Клинического института детского здоровья имени Н.Ф. Филатова ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский университет); профессор гематологии, университет Монпелье

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4,

34090 Монпелье, ул. Огюста Бруссоне, д. 163

Researcher ID: AAA-2923-2019

Jean-Christophe Gris – MD, Dr Sci Med, Professor, Department of Obstetrics and Gynecology, Filatov Clinical Institute of Children’s Health, Sechenov University; University of Montpellier, Montpellier, France; Foreign Member of RAS

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991,

163 Rue Auguste Broussonnet, Montpellier 34090

Researcher ID: AAA-2923-2019

https://orcid.org/0000-0003-4467-240X

Ди Ренцо

Д. К.

Di Renzo

G. C.

Ди Ренцо Джан Карло – доктор медицинских наук, профессор кафедры акушерства и гинекологии Клинического института детского здоровья имени Н.Ф. Филатова ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский университет); директор Центра пренатальной и репродуктивной медицины Университета Перуджи, Италия; почетный генеральный секретарь Международной федерации акушеров-гинекологов (FIGO)

Умбрия, Перуджа, Piazza Italia

Scopus Author ID: 7103191096,

Researcher ID: P-3819-2017

Gian C. Di Renzo – MD, Dr Sci Med, Professor, Department of Obstetrics and Gynecology, Filatov Clinical Institute of Children’s Health, Sechenov University; Director of the Center for Prenatal and Reproductive Medicine, University of Perugia; Honorary Secretary General of the International Federation of Gynecology and Obstetrics (FIGO)

Umbria, Perugia, Piazza Italia

Scopus Author ID: 7103191096,

Researcher ID: P-3819-2017

https://orcid.org/0000-0001-5888-0774

Цибизова

В. И.

Tsibizova

V. I.

Цибизова Валентина Ивановна – кандидат медицинских наук, акушер-гинеколог НИЛ оперативной гинекологии Института перинатологии и педиатрии; врач отделения функциональной и ультразвуковой диагностики

197341 Санкт-Петербург, ул. Аккуратова, д. 2

Valentina I. Tsibizova – MD, PhD, Obstetrician-Gynecologist, Research Laboratory of Operative Gynecology, Institute of Perinatology and Pediatrics; Physician, Department of Functional and Ultrasound Diagnostics

2 Akkuratova Str., Saint Petersburg 197341

https://orcid.org/0000-0002-3367-9844

Блинов

Д. В.

Blinov

D. V.

Блинов Дмитрий Владиславович – кандидат медицинских наук, руководитель по медицинским и научным вопросам, Институт Превентивной и Социальной Медицины; врач-невролог, Клинический Госпиталь Лапино, ГК «Мать и Дитя»

127006 Москва, ул. Садовая-Триумфальная, д. 4–10,

143081 Московская область, Одинцовский район, Лапино, 1-е Успенское шоссе, д. 111

Scopus Author ID: 6701744871,

Researcher ID: E-8906-2017,

RSCI: 9779-8290

Dmitry V. Blinov – MD, PhD, MBA, Head of Medical and Scientific Affairs, Institute for Preventive and Social Medicine; Neurologist, Lapino Clinical Hospital, MD Medical Group

4–10 Sadovaya-Triumfalnaya Str., Moscow 127006,

1st Uspenskoe Highway, 111, Moscow Region, Odintsovo District, Lapino 143081

Scopus Author ID: 6701744871,

Researcher ID: E-8906- 2017,

RSCI: 9779-8290

https://orcid.org/0000-0001-7415-4633

Макацария

А. Д.

Makatsariya

A. D.

Макацария Александр Давидович – доктор медицинских наук, профессор, академик РАН, заведующий кафедрой акушерства и гинекологии Клинического института детского здоровья имени Н.Ф. Филатова

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4

Scopus Author ID: 57222220144,

Researcher ID: M-5660-2016

Alexander D. Makatsariya – MD, Dr Sci Med, Academician of RAS, Professor, Head of the Department of Obstetrics and Gynecology, Filatov Clinical Institute of Children’s Health

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

Researcher ID: M-5660-2016

ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский университет)РоссияSechenov UniversityRussian Federation

ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский университет); ФГБНУ «Российский научный центр хирургии имени академика Б.В. Петровского»РоссияSechenov University; Petrovsky National Research Centre of SurgeryRussian Federation

ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский университет); Университет МонпельеРоссияSechenov University; University of MontpellierRussian Federation

Центр пренатальной и репродуктивной медицины Университета ПеруджиИталияCenter for Prenatal and Reproductive Medicine, University of PerugiaItaly

ФГБУ «Национальный медицинский исследовательский центр имени В.А. Алмазова» Министерства здравоохранения Российской ФедерацииРоссияAlmazov National Medical Research Centre, Health Ministry of Russian FederationRussian Federation

Институт Превентивной и Социальной Медицины; Клинический Госпиталь Лапино, ГК «Мать и Дитя»РоссияInstitute for Preventive and Social Medicine; Lapino Clinic Hospital, MD Medical GroupRussian Federation

2022

12072022

163306316

2022

Григорьева К.Н., Бицадзе В.О., Хизроева Д.Х., Слуханчук Е.В., Третьякова М.В., Макацария Н.А., Гри Ж.А., Ди Ренцо Д.К., Цибизова В.И., Блинов Д.В., Макацария А.Д.

Grigoreva K.N., Bitsadze V.O., Khizroeva J.K., Slukhanchuk E.V., Tretyakova M.V., Makatsariya N.A., Gris J., Di Renzo G.C., Tsibizova V.I., Blinov D.V., Makatsariya A.D.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.gynecology.su/jour/article/view/1361

Preeclampsia (PE) is a multisystemic disease that has been recorded as a complication in up to 15 % of pregnancies being lead cause of maternal mortality worldwide. Despite that PE pathophysiology has not been fully elucidated, it is currently believed that the endothelial dysfunction and pro-inflammatory status play a key role in its development, which account for impaired implantation processes as well as trophoblast invasion during placentation. Altogether, it results in developing generally accepted clinical symptoms “triad”: arterial hypertension, proteinuria, and edema. PE is also characterized by clotting disorders that cause an increased risk of maternal venous thromboembolism. It should be remembered that the related risk may be markedly elevated in the postpartum period. The mechanisms underlying the development of thrombosis high risk remain to be fully investigated, albeit upregulated expression of procoagulant factors, endothelial dysfunction, compromised endogenous anticoagulant activity, and increased platelet activity result in prothrombotic predisposition.

Преэклампсия (ПЭ) – это мультисистемное заболевание, которое и по сей день осложняет до 15 % беременностей и является ведущей причиной фето-материнской смертности во всем мире. Несмотря на то что патофизиология ПЭ до конца не ясна, считается, что ключевую роль в развитии данного состояния играет эндотелиальная дисфункция и провоспалительный статус, которые обуславливают нарушение процессов имплантации, инвазии трофобласта и плацентации. Все это приводит к развитию общепринятой клинической триаде симптомов: артериальной гипертензии, протеинурии и отекам. Для ПЭ также характерны нарушения свертывания крови, которые способствуют повышенному риску венозной тромбоэмболии у таких женщин. Надо помнить, что этот риск значительно увеличивается в послеродовом периоде. Механизмы, лежащие в основе развития высокого риска тромбозов, еще предстоит выяснить до конца, хотя повышенная экспрессия прокоагулянтных факторов, эндотелиальная дисфункция, ослабление эндогенной антикоагулянтной активности и повышенная активность тромбоцитов ведут к протромботическому уклону.

преэклампсияПЭбеременностьвенозная тромбоэмболия эндотелиальная дисфункция

preeclampsiaPEpregnancyvenous thromboembolismendothelial dysfunction

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The authors declare that there are no conflicts of interest present.