akusherstvoObstetrics, Gynecology and ReproductionАкушерство, Гинекология и Репродукция2313-73472500-3194IRBIS LLCakusherstvo-13Research ArticleGYNECOLOGYГИНЕКОЛОГИЯMAGNESIUM DEFICIENCY IN OBSTETRICS AND GYNECOLOGYДЕФИЦИТ МАГНИЯ В АКУШЕРСТВЕ И ГИНЕКОЛОГИИДадакК.DadakC.christian.dadak@meduniwien.ac.atДепартамент акушерства и гинекологии, Кафедра фундаментального и углубленного международного высшего образования, Венский медицинский университетАвстрияDepartment of Gynecology and Obstetrics, Department of basic and advanced international postgraduate education, Medical University of Vienna (Austria)Austria20133105201672614Copyright © Dadak C., 20162016Дадак К.Dadak C.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gynecology.su/jour/article/view/13

Biological role of magnesium in the human body is proved and very well-known. The pathogenesis of obstetrics and gynecology pathology shows that, next to magnesium, pyridoxine plays a key role. An effective strategy for prevention premature delivery, preeclampsia and eclampsia is proved to be timely magnesium sulfate application. We also have facts about its neuroprotective effect on the fetus. However the possibility of overdosage and serious side effects lead to a restricted usage of magnesium sulfate. To minimize the risk of overdosage, its necessary to follow the standard protocols, to make independent crosscheck and to monitor the condition of the patient. Its also reasonable to take magnesium sulfateorally - apart from better bioavailability,overdosage won’t cause serious side effects. Organic magnesium sulfate for magnesium deficiency control and associated symptoms is also justified for premenstrual syndrome (PMS), when COC (Combined Oral Contraceptives) and HRT (hormonal replacement therapy) is prescribed for women undergoing menopause. Magnesium citrate is more preferable because citrate-anion facilitates high bioavailability of magnesium, its also necessary in Krebs cycle and it turns into carbon dioxide and water. Due to this citrate is a perfect transporter of magnesium to the cells.

Биологическая роль магния в организме доказана и хорошо известна. Б патогенезе акушерско-гинекологической патологии, наряду с магнием, играет роль и пиридоксин. Эффективной тактикой борьбы с преждевременными родами, преэклампсией и эклампсией признано своевременное применение сульфата магния. Есть данные и о его нейропротекторном воздействии на плод. Однако возможность передозировки с развитием серьезных побочных эффектов ограничивает применение сульфата магния. Свести риск передозировки к минимуму можно благодаря использованию стандартных протоколов, независимой двойной проверки, мониторингу состояния пациента. Также оправданно использование органических солей магния перорально - наряду с лучшей биодоступностью их применение приводит к серьезным побочным эффектам при передозировке. Использование органических солей магния для контроля магниевого дефицита и связанных с ним симптомов показано также при ПМС, назначении КОК и ЗГТ при климаксе. Применение цитрата магния является наиболее предпочтительным, так как цитрат-анион обуславливает высокую биоусвояемость магния, он также необходим в цикле Кребса и утилизируется в углекислый газ и воду. Это делает цитрат идеальным переносчиком магния в клетки.

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The authors declare that there are no conflicts of interest present.