akusherstvoObstetrics, Gynecology and ReproductionАкушерство, Гинекология и Репродукция2313-73472500-3194IRBIS LLC10.17749/2313-7347/ob.gyn.rep.2021.166akusherstvo-1128Research ArticleREVIEW ARTICLESНАУЧНЫЕ ОБЗОРЫMucociliary apparatus of the fallopian tubes and related pathogenetic aspects contributing to infertility and prospects for correction (analytical review)Мукоцилиарный аппарат маточных труб и патогенетические аспекты его нарушений, их роль в бесплодии и перспективы коррекции (аналитический обзор)https://orcid.org/0000-0002-1523-9669КобылянскийВ. И.KobylyanskyV. I.

Кобылянский Вячеслав Иванович – доктор медицинских наук, профессор образовательного центра

105077 Москва, ул. 11-я Парковая, д. 32, корп. 4

Vyacheslav I. Kobylyansky – MD, Dr Sci Med, Professor, Educational Center, Federal Pulmonology Research Institute

32 bldg. 4, 11th Parkovaya Str., Moscow 105077

kobylyansky@mail.ruФГБУ «Научно-исследовательский институт пульмонологии Федерального медико-биологического агентства России»РоссияFederal Pulmonology Research Institute, Federal Medical and Biological Agency of RussiaRussian Federation202103112021155586598Copyright © Kobylyansky V.I., 20212021Кобылянский В.И.Kobylyansky V.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gynecology.su/jour/article/view/1128Introduction

Introduction. The mucociliary apparatus (MCA) of the fallopian tubes (MTр) represents one of the key mechanisms and arms in functioning of female reproductive system. A prominent role of impaired MCA in the pathogenesis of reproductive system diseases and infertility, on the one hand, as well as insufficient knowledge and elucidation of this topic, on the other hand, spurred current study.

Aim

Aim: to improve our understanding about a role for reproductive system MCA and its impairment in developing diseases and infertility, as well as to identify potential perspectives for their correction.

Materials and Methods

Materials and Methods. We searched for publications and analyzed literature data from 1980 to 2020 using various scientific databases, including Index Medicus, PubMed/MEDLINE, Embase, Cochrane Library and Russian scholarly journals related to gynecology, obstetrics and reproduction.

Results

Results. The analysis conducted allowed to originally assess the morpho-functional, structural-genetic features and other important aspects of MCA MTр. In addition, we demonstrated an impact of various factors on developing diverse types of pathological processes, including those capable of causing infertility. Moreover, we also elucidated a state of MCA MTр coupled to various diseases, including genetically determined disorders.

Conclusion

Conclusion. The role of impaired MCA MTр in developing pathological process and infertility was of tremendous importance and deserves close attention, because they are often remained undiagnosed by standard methods and require use of morphological and functional research methods for verification. Perspectives for diagnostics and correction of MCA MTр disorders are further discussed.

 

 

Введение

Введение. Одним из ключевых механизмов и звеньев в функционировании репродуктивной системы женщины является мукоцилиарный аппарат (МЦА) маточных труб (МТр). Огромная роль его нарушений в патогенезе заболеваний репродуктивных органов и бесплодии, с одной стороны, и недостаточная изученность и освещенность этой темы в литературе, с другой, явились инициирующими факторами для проведения настоящей работы.

Цель исследования

Цель исследования: усовершенствовать представления о МЦА репродуктивных органов и о роли его нарушений в развитии заболеваний и бесплодия, а также выявить возможные перспективы коррекции этих нарушений.

Материалы и методы

Материалы и методы. Проведен поиск публикаций и анализ литературных данных путем использования различных научных баз, включая Index Medicus, PubMed/MEDLINE, Embase, Cochrane Library и российские профильные журналы, касающиеся гинекологии, акушерства и репродукции. Поиск осуществлялся за значительный период времени – c 1980 по 2020 гг.

Результаты

Результаты. Анализ позволил в оригинальном разрезе показать морфофункциональные, структурно-генетические особенности и другие важные аспекты МЦА МТр. Продемонстрировано влияние различных факторов в развитии разного рода патологического процесса, в том числе способного стать причиной бесплодия. Кроме того, отражено состояние МЦА МТр на фоне заболеваний, включая генетически детерминированные.

Заключение

Заключение. Роль нарушений МЦА МТр в развитии патологического процесса и бесплодии значительна и заслуживает пристального внимания, поскольку эти нарушения нередко не диагностируются стандартными методами и требуют для их верификации использования морфофункциональных способов исследования. Рассматриваются перспективы диагностики и коррекции нарушений МЦА МТр.

 

 

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The authors declare that there are no conflicts of interest present.