akusherstvoObstetrics, Gynecology and ReproductionАкушерство, Гинекология и Репродукция2313-73472500-3194IRBIS LLC10.17749/2313-7347/ob.gyn.rep.2021.233akusherstvo-1066Research ArticleREVIEW ARTICLESНАУЧНЫЕ ОБЗОРЫNeonatal thrombosis: risk factors and principles of prophylaxisФакторы риска и принципы профилактики неонатальных тромбозовhttps://orcid.org/0000-0002-4509-9281ВоробьевА. В.VorobevA. V.

Воробьев Александр Викторович - кандидат медицинских наук, доцент кафедры акушерства и гинекологии Клинического института детского здоровья имени Н.Ф. Филатова.

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4.

Researcher ID: F-8804-2017.

Scopus Author ID: 57191966265.

Alexander V. Vorobev - MD, PhD, Associate Professor, Department of Obstetrics and Gynecology, Filatov Clinical Institute of Children's Health, Sechenov University.

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991.

Researcher ID: F-8804-2017.

Scopus Author ID: 57191966265.

alvorobev@gmail.comhttps://orcid.org/0000-0001-8404-1042БицадзеВ. О.BitsadzeV. O.

Бицадзе Виктория Омаровна - доктор медицинских наук, профессор РАН, профессор кафедры акушерства и гинекологии Клинического института детского здоровья имени Н.Ф. Филатова.

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4.

Scopus Author ID: 6506003478.

Researcher ID: F-8409-2017.

Victoria O. Bitsadze - MD, Dr Sci Med, Professor of RAS, Professor, Department of Obstetrics and Gynecology, Filatov Clinical Institute of Children's Health, Sechenov University.

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991.

Scopus Author ID: 6506003478.

Researcher ID: F-8409-2017.

https://orcid.org/0000-0002-0725-9686ХизроеваД. Х.KhizroevaJ. Kh.

Хизроева Джамиля Хизриевна - доктор медицинских наук, профессор кафедры акушерства и гинекологии Клинического института детского здоровья имени Н.Ф. Филатова.

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4.

Scopus Author ID: 57194547147.

Researcher ID: F-8384-2017.

Jamilya Kh. Khizroeva - MD, Dr Sci Med, Professor, Department of Obstetrics and Gynecology, Filatov Clinical Institute of Children's Health, Sechenov University.

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991.

Scopus Author ID: 57194547147.

Researcher ID: F-8384-2017.

https://orcid.org/0000-0002-6519-8762ПотапкинаС. A.PotapkinaS. A.

Потапкина Софья Арсеньевна - студент Клинического института детского здоровья имени Н.Ф. Филатова.

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4.

Sophia A. Potapkina - Student, Filatov Clinical Institute of Children's Health, Sechenov University.

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991.

https://orcid.org/0000-0002-2541-3843МакацарияН. А.MakatsariyaN. A.

Макацария Наталия Александровна - кандидат медицинских наук, доцент кафедры акушерства и гинекологии Клинического института детского здоровья имени Н.Ф. Филатова.

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4.

Researcher ID: F-8406-2017.

Nataliya A. Makatsariya - MD, PhD, Associate Professor, Department of Obstetrics and Gynecology, Filatov Clinical Institute of Children's Health, Sechenov University.

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991.

Researcher ID: F-8406-2017.

https://orcid.org/0000-0002-5525-4353РиццоД.RizzoG.

Риццо Джузеппе - доктор медицинских наук, профессор кафедры акушерства и гинекологии Клинического института детского здоровья имени Н.Ф. Филатова ПМГМУ им. И.М. Сеченова МЗ РФ (Сеченовский университет); профессор, директор департамента перинатологии, Римский университет Тор Вергата.

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4; Рим.

Scopus Author ID: 7102724281.

Researcher ID: G-8234-2018.

Giuseppe Rizzo - MD, Dr Sci Med, Professor, Department of Obstetrics and Gynecology, Filatov Clinical Institute of Children's Health, Sechenov University; Professor, Director, Division of Maternal and Fetal Medicine, Ospedale Cristo Re, University of Rome Tor Vergata.

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991; Rome.

Scopus Author ID: 7102724281.

Researcher ID: G-8234-2018.

https://orcid.org/0000-0003-4467-240XДи РенцоД. К.Di RenzoG. C.

Ди Ренцо Джан Карло - доктор медицинских наук, профессор кафедры акушерства и гинекологии Клинического института детского здоровья имени Н.Ф. Филатова ПМГМУ им. И.М. Сеченова МЗ РФ (Сеченовский университет); директор Центра пренатальной и репродуктивной медицины Университета Перуджи; почетный генеральный секретарь Международной федерации акушеров-гинекологов (FIGO).

119991 Москва, ул. Большая Пироговская, д. 2, стр. 4; Умбрия, Перуджа, Piazza Italia.

Scopus Author ID: 7103191096.

Researcher ID: P-3819-2017.

Gian C. Di Renzo - MD, Dr Sci Med, Professor, Department of Obstetrics and Gynecology, Filatov Clinical Institute of Children's Health, Sechenov University; Director of the Center for Prenatal and Reproductive Medicine, University of Perugia; Honorary Secretary General of the International Federation of Gynecology and Obstetrics (FIGO).

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991; Umbria, Perugia, Piazza Italia.

Scopus Author ID: 7103191096.

Researcher ID: P-3819-2017.

https://orcid.org/0000-0002-3367-9844БлиновД. В.BlinovD. V.

Блинов Дмитрий Владиславович - кандидат медицинских наук, руководитель по медицинским и научным вопросам, Институт Превентивной и Социальной Медицины; врач-невролог, Клинический Госпиталь Лапино, ГК «Мать и Дитя».

127006 Москва, ул. Садовая-Триумфальная, д. 4—10; 143081 Московская область, Одинцовский район, Лапино, 1-е Успенское шоссе, д. 111.

Scopus Author ID: 6701744871.

Researcher ID: E-8906-2017. RSCI: 9779-8290.

Dmitry V. Blinov - MD, PhD, MBA, Head of Medical and Scientific Affairs, Institute for Preventive and Social Medicine; Neurologist, Lapino Clinical Hospital, MD Medical Group.

4—10 Sadovaya-Triumfalnaya Str., Moscow 127006; 1st Uspenskoye Highway, 111, Moscow Region, Odintsovo District, Lapino 143081.

Scopus Author ID: 6701744871.

Researcher ID: E-8906-2017. RSCI: 9779-8290.

https://orcid.org/0000-0002-1339-4155ПанкратьеваЛ. Л.PankratyevaL. L.

Панкратьева Людмила Леонидовна - доктор медицинских наук, руководитель научно-клинического центра, ГКБ № 67 им. Л.А. Ворохобова ДЗ г. Москвы; врач-неонатолог, врач-гематолог, доцент, профессор кафедры педиатрии и организации здравоохранения НМИЦ ДГОИ им. Дмитрия Рогачева МЗ РФ.

123423 Москва, ул. Саляма Адиля, д.2/44; 117997 Москва, ул. Саморы Машела, д. 1.

Scopus Author ID: 7006391091.

Author ID: 697284.

Liudmila L. Pankratyeva - MD, Dr Sci Med, Head of the Clinical Research Center, Vorokhobov City Clinical Hospital № 67; Neonatologist, Hematologist, Associate Professor, Professor of the Department of Pediatrics and Health Organization, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology.

2/44 Salyama Adilya Str., Moscow 123423; 1 Samora Machel Str., Moscow 117997.

Scopus Author ID: 7006391091.

Author ID: 697284.

https://orcid.org/0000-0001-5888-0774ЦибизоваВ. И.TsibizovaV. I.

Цибизова Валентина Ивановна - кандидат медицинских наук, врач акушер-гинеколог НИЛ оперативной гинекологии Института перинатологии и педиатрии; врач отделения функциональной ультразвуковой диагностики.

197341 Санкт-Петербург, ул. Аккуратова, д. 2.

Valentina I. Tsibizova - MD, PhD, Obstetrician-Gynecologist, Research Laboratory of Operative Gynecology, Institute of Perinatology and Pediatrics; Physician, Department of Functional and Ultrasound Diagnostics, Almazov National Medical Research Centre.

2 Akkuratova Str., Saint Petersburg 197341.

Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет)РоссияSechenov UniversityRussian FederationПервый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет); Римский университет Тор ВергатаРоссияSechenov University; University of Rome Tor VergataRussian FederationПервый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет); Центр пренатальной и репродуктивной медицины Университета ПеруджиРоссияSechenov University; Center for Prenatal and Reproductive Medicine, University of PerugiaRussian FederationИнститут Превентивной и Социальной Медицины; Клинический Госпиталь Лапино, ГК «Мать и Дитя»РоссияInstitute for Preventive and Social Medicine; Lapino Clinic Hospital, MD Medical GroupRussian FederationГородская клиническая больница № 67 имени Л.А. Ворохобова Департамента здравоохранения города Москвы; Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии имени Дмитрия Рогачева Министерства здравоохранения Российской ФедерацииРоссияVorokhobov City Clinical Hospital № 67, Moscow Healthcare Department; Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Health Ministry of Russian FederationRussian FederationНациональный медицинский исследовательский центр имени В.А. Алмазова Министерства здравоохранения Российской ФедерацииРоссияAlmazov National Medical Research Centre, Health Ministry of Russian FederationRussian Federation202108092021154390403Copyright © Vorobev A.V., Bitsadze V.O., Khizroeva J.K., Potapkina S.A., Makatsariya N.A., Rizzo G., Di Renzo G.C., Blinov D.V., Pankratyeva L.L., Tsibizova V.I., 20212021Воробьев А.В., Бицадзе В.О., Хизроева Д.Х., Потапкина С.A., Макацария Н.А., Риццо Д., Ди Ренцо Д.К., Блинов Д.В., Панкратьева Л.Л., Цибизова В.И.Vorobev A.V., Bitsadze V.O., Khizroeva J.K., Potapkina S.A., Makatsariya N.A., Rizzo G., Di Renzo G.C., Blinov D.V., Pankratyeva L.L., Tsibizova V.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gynecology.su/jour/article/view/1066

Data analysis on the pathogenesis and risk factors of neonatal thrombosis was carried out. The main risk factor of any neonatal thrombosis is central catheter installment, but other maternal, fetal and neonatal factors should be taken into consideration. We discuss the epidemiology of neonatal thrombosis and the main features of the hemostasis system in newborns, the most significant risk factors, including genetic and acquired thrombophilia. We consider the von Willebrand factor activity and ADAMTS-13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) level in the development of neonatal thrombotic microangiopathy. Finally, we discuss the basic principles of prevented neonatal thrombosis by using low molecular weight heparins.

Проведен анализ данных о патогенезе и факторах риска неонатальных тромбозов. В обзор включены данные зарубежных и отечественных статей по данной теме. В значительной степени неонатальные тромбозы возникают из-за наличия центрального катетера, однако существуют и другие факторы риска как со стороны матери, так и со стороны самого новорожденного. Представлены данные по эпидемиологии неонатальных тромбозов, особенностям функционирования системы гемостаза у новорожденных, рассмотрены наиболее значимые факторы риска, в том числе генетическая и приобретенная тромбофилия. Рассмотрены вопросы значения активности фактора фон Виллебранда и уровня ADAMTS-13 (англ. a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) в развитии тромботической микроангиопатии у новорожденных. Дана информация по основным принципам профилактики неонатальных тромбозов с применением низкомолекулярных гепаринов.

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The authors declare that there are no conflicts of interest present.